Blog posts by andrew

Multiple peak solvent suppression with 13C decoupling

June 25th, 2019, by

In a previous post we demonstrated the use of multiple peak solvent suppression on the Spinsolve ULTRA benchtop NMR spectrometer.  While the sequence effectively suppressed 3 NMR solvent peaks, it did not reduce the carbon satellites of the solvent which are at a different frequency, and had a similar intensity to our compound of interest and therefore might interfere with our measurements. Fortunately on a Spinsolve ULTRA Carbon spectrometer we can use the carbon channel to do 13C decoupling at the same time as suppressing the solvent peaks.  An example of multiple peak solvent suppression with carbon decoupling is shown below in Figure 1. Notice how the peak labelled with the purple dot is revealed once the carbon satellites are suppressed.

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Multiple Peak Solvent Suppression

June 25th, 2019, by

The Spinsolve ULTRA is able to suppress multiple solvent peaks (up to 3 separate peaks) which allows you to resolve compounds dissolved at sub-millimolar concentrations in protonated organic solvents, such as ethanol.  While single peak solvent suppression is useful for samples where water is the solvent, many organic solvents have multiple strong NMR peaks.  If you want to resolve or quantify compounds dissolved in an organic solvent, the ability to suppress all the solvent peaks is very useful as shown in Figure 1 below.

Figure 1: The image above shows a zoom of 1D proton spectrum of 170mM Paracetamol dissolved in normal protonated Ethanol acquired on a Spinsolve 60 ULTRA (top, red). The second spectrum (bottom, blue) shows the same sample acquired with multiple peak solvent supression at the frequencies indicated by the 3 red arrows.

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Spinsolve 80 Phosphorus – Limit of Detection

May 29th, 2019, by

The best-selling Magritek 80 MHz Spinsolve benchtop NMR is also available with the X-channel set to 31-Phosphorus.  31P NMR spectroscopy is routinely used by chemists to determine structure and measure impurities.  When looking for impurities it is important to know the lower limit of detection (LOD). The LOD is the lowest concentration of a molecule that can be distinguished from the absence  of that molecule.

In NMR it is the sensitivity that determines the  LOD for a particular substance, and the higher magnetic field of an 80 MHz magnet brings a number of advantages including increased sensitivity.  We thought it would be interesting to determine the LOD for tetramethylphosphonium chloride with different acquisition times.  We defined the LOD as an NMR peak with signal height that was 3 times the noise level, i.e. an SNR of 3.


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Introducing the new Spinsolve Autosampler

February 18th, 2019, by

We are very excited to announce the launching of our new Spinsolve Autosampler.  It enables up 20 separate samples to be measured in any order and can be fitted to all Spinsolve models.  We have been developing this for some time, and already have quite a number of units with some of our reference customers who tell us they are delighted with its operation, functionality and high quality construction.

The Autosampler is particularly useful for customers who often have a series of samples to run on their benchtop NMR and want to save the hassle of having to keep coming back to exchange samples. Another benefit is the ability to increase utilization by setting up a queue of experiments to run on their Spinsolve overnight.

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DEA awards contract to Magritek Inc. to supply 80 MHz benchtop NMR spectrometers complete with autosamplers for forensic applications.

December 5th, 2018, by

Malvern, PA, USA, 4th December 2018: Magritek announces that it has been awarded a major contract by the US Drug Enforcement Administration (DEA) for two Spinsolve 80 Carbon benchtop NMR spectrometers. The purchase was made through a competitive award process and will allow DEA laboratories in Virginia and California to utilize the latest benchtop NMR technology to assist in forensic analysis applications.

Speaking about this prestigious award, Magritek Inc’s CEO, Dr Hector Robert, says

“We are very excited to be awarded this contract by the DEA. The selection of the 80 MHz Spinsolve instrument with 1H, 19F and 13C nuclei provides a versatile system suited to the analysis of many substances studied in forensic science. The systems are supplied with autosamplers which enable the measurement of multiple samples with an automated and efficient workflow.”

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Boron NMR Spectroscopy

November 29th, 2018, by

There are two naturally occurring NMR active nuclei of Boron, 11B (80.1%) and 10B (19.9%). Both nuclei are quadrupolar with spin of greater than ½. 11B has a spin of 3/2 and 10B is spin 3. In terms of sensitivity, 11B is the better nucleus to use as it has a higher natural abundance, a higher gyromagnetic ration, and a lower quadrupole moment. A Spinsolve benchtop NMR spectrometer with a proton frequency of 60 MHz can be configured to measure the 11B NMR signal which has a frequency of 19.2 MHz.

The 11B NMR spectrum of a 0.23 M solution Sodium tertraphenylborate in MeOH-d4 is shown below. The first spectrum shows the excellent sensitivity of Spinsolve using just 8 scans to acquire a spectrum in only 16 seconds.

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Live Benchtop NMR monitoring of Corning Flow Reactors at Achema

June 11th, 2018, by

At the Achema conference this week in Frankfurt we have a joint booth with Corning Advanced Flow Reactors.  We are running a live Spinsolve Benchtop NMR reaction monitoring setup in combination with a Corning Advanced Flow Reactor.  If you are Achema, please come and visit us at our joint booth with Corning AFR Hall 9.2 / Booth A32 and see the powerful combination of Corning Flow Reactors and Magritek Benchtop NMR.

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Characterizing Fatty Acids with advanced multinuclear NMR methods

April 6th, 2018, by

Download the full application note by clicking here (PDF)

Fatty acids consist of long carbon chains ending with a carboxylic acid on one side and a methyl group on the other. Most naturally occurring fatty acids have an even number of carbon atoms and can be either saturated or unsaturated. Unsaturated fatty acids have one or more double bonds between carbon atoms. Typical fatty acids found in vegetable oils are saturated palmitic acid (C16:0) and stearic acid (C18:0), as well as oleic acid (C18:1) with a single double bond starting at carbon nine (omega-9), linoleic acid (C18:2) with two double bonds starting at position 6 (omega-6), and alpha-linolenic acid with three double bonds starting at position 3 (omega-3).
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Thought Leader Interview: Prof Patrick Giraudeau

February 19th, 2018, by

A fascinating thought leader interview with Prof Patrick Giraudeau from the University of Nantes discusses how his group uses their Spinsolve benchtop NMR spectrometer for applications such as reaction monitoring, edible oil analysis and implementing ultrafast 2D NMR.

Benchtop NMR systems are better suited to reaction monitoring than high-field systems

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About andrew

Andrew is the CEO of Magritek and has led the company from its foundation as a University spin out company to its current position as a fast-growing, profitable exporter. He brings both commercial and technical experience to the company having worked in senior management roles for companies in Sydney and London. Andrew has a PhD in Physics from Massey University, is a 2011 Sir Peter Blake Emerging Leader and was a member of the team that won the 2010 Prime Minister’s Science Prize.