Monitoring and Self-Optimising of Chemical Reactions with Benchtop NMR
Benchtop NMR systems have become popular for research and teaching in chemistry labs. Magritek’s Spinsolve is being used at the University of Glasgow to monitor and optimise chemical reactions.
Inspired by previous self-optimised flow systems with in-line analytical monitoring, the Group of Professor Lee Cronin has extended this concept so that multinuclear and 2D NMR can be performed in the fume hood. The Spinsolve benchtop NMR provides analyses ranging from a single sample in a standard 5 mm NMR tube, to performing in-line 1H, 13C, 19F and 2D NMR analyses. They have also combined in-line 1H NMR with computational techniques to make a self-optimising reactor and have created a flow system which operates using non-deuterated solvents and nothing more than simple plastic tubing.