Hear about what Magritek customers have to say about their Spinsolve.
Hear from Education Customers
- Dr Hilde Roex – University College Leuven Limburg, Belgium
- Dr Irosha Nawarathne – Lyon College, Arkansas
- Dr Stanislav Presolski – Yale-NUS College
- Dr Leena Kaisalo – University of Helsinki
- Professor Cyrille Monnereau – ENS de Lyon
- Dr Michael King – George Washington University
- Dr Vania De Paoli – Cleveland State University
- Dr Harald Baumgartner – HTBLA Wels
- Dr Maria Vogt – Bloomfield College
- Dr Kaveh Azimi – Tarrant County College
- Dr Paul Wiget – Samford University
- Meredith Moses – Virginia Commonwealth University
- Dr Jonathan Harburn – Durham University (Pharmacy)
- Dr Alan Kenwright – Durham University (Chemistry)
- Dr Philip Sharpe – University of Queensland
- Dr Marlon Jones – Long Beach City College
- Dr Teris van Beek – Wageningen University & Research, The Netherlands
- Dr Joseph Hornack – Rochester Institute of Technology
- Professor Magid Abou-Gharbia – Temple University
Hear from Research Customers
- Dr Andrew York – Johnson Matthey Technology Centre
- Dr Patrick Giraudeau – University of Nantes
- Professor Lee Cronin – University of Glasgow
- Dr Michael Maiwald – BAM Institute
- Dr Mario Killner – University of Campinas
- Dr Theo Dingemans – TU Delft
- Dr Jeroen Geuens – Karel de Grote University College
- Dr Peter Keizers – Centre for Health Protection at RIVM
- Professor Stephen Ley – Department of Chemistry, University of Cambridge
Dr Hilde Roex
University College Leuven Limburg, Belgium
Dr Hilde Roex is the co-ordinator of the second year organic chemistry laboratory course of the Chemistry Program (Gasthuisberg campus, Faculty Management & Technology). Here, the students apply NMR in their organic chemistry laboratory to identify the molecular structure of their synthesized products. They are taught to see the value of NMR for quality control and its use alongside other analytical methods including gas and liquid chromatography. Their goal is to be able to interpret proton NMR spectra and to learn that proton NMR and FT-IR spectroscopy are complementary techniques. This helps to make students familiar with NMR showing them applications of its wide use in industry.
UCLL chose the Magritek Spinsolve Benchtop NMR due to its ease of use. Sample loading and cleaning is simple compared to competitive models that use tubing rather than standard 5 mm NMR sample tubes. Magritek’s Spinsolve resembles the performance of a superconducting NMR and fits closer to theory too. Running a spectrum is very simple, yet very effective as illustrated in the examples from the students’ practical sessions. Dr Roex explains the method she used with this year’s second semester group of students.
Students had to synthesise an alkyl bromide out of an unknown alcohol, as described in literature. Next, they had to control the purity and interpret the 1H NMR spectrum of their obtained alkyl bromide. Finally, they had to define their unknown alcohol by comparing its spectrum with a range of pre-defined alcohol spectra.
Dr Irosha Nawarathne
Chemistry Department at Lyon College, Arkansas
Dr Irosha Nawarathne is an Assistant Professor in the Chemistry Department at Lyon College, a selective liberal arts institution in rural Arkansas. Her work bridges biomedical research to teaching students the practical use of instrumentation to prepare them for employment and the challenges of the chemical industry. She summarizes her experience with the Spinsolve, which was added to the Chemistry Department in 2015. About the teaching she notes:
Spinsolve has become the most popular among faculty and students of our chemistry program. It is used in organic chemistry, instrumental analysis, and advanced inorganic chemistry laboratories. We plan to extend the usage to other areas too. Students have become very interested in the concept of NMR because of this instrument. Their knowledge of NMR is improved tremendously after the incorporation of Spinsolve in the chemistry program. It is easy to operate, provides quick analysis, and requires very low maintenance. Spinsolve is definitely the best fit for a small college like ours. We formerly had a cryogenic NMR spectrometer at Lyon but the chemistry program has not been able to maintain the instrument in the long term. Spinsolve is low cost and its low maintenance is key for its great fit to Lyon chemistry program. It is also used in recruiting keen students as they get really excited about the instrument and its capabilities during frequent campus tours.
Then she adds a few words about the use of Spinsolve in her research:
NMR provides detailed structure of the molecule within a very short time compared to the other instruments. The students feel very confident and satisfied with their laboratory accomplishments using the Spinsolve. We incorporate all the available instruments in instrumental analysis and advanced inorganic chemistry classes for students’ benefit. Since spring 2017, several applications of Spinsolve were utilized to analyze paramagnetic and organometallic compounds. Such is the delight to have the Spinsolve at Lyon, we are also in the process of seeking funds for the purchase of the 13C console of Spinsolve.
Dr Stanislav Presolski
Yale-NUS College, Singapore
Dr Stanislav Presolski is an assistant professor in chemistry at Yale-NUS. While in research, his goals are to harness his synthetic and physical-organic chemistry experience in leading a research group of undergraduates, who will design, prepare and deploy operationally simple, photo-switchable catalytic molecules, it is in the area of teaching techniques to students where he is taking a fresh approach.
We have designed our science classes in a way that makes them fairly indistinguishable from actual research.
Dr Presolski’s classes are quite small – fewer than 18 students per class. This means that professors are able to give tailored instruction to their students and provide the key skills needed to properly use the scientific equipment.
You are taught not only how to operate the machines, but also the physical principles behind the measurements and ways to interpret the data without reliance on the default software
Dr Leena Kaisalo
Department of Chemistry at University of Helsinki, Finland
Dr Leena Kaisalo heads up the Organic Chemistry student laboratory at the University of Helsinki. While the Laboratory’s research focuses on organic synthesis, Dr Kaisalo’s role is to lead the teaching of bachelor and masters students in various analytical techniques including NMR. Before her laboratory got a Magritek Spinsolve benchtop NMR spectrometer, the teaching assistants used to run NMR spectra for the students using 300 or 500 MHz spectrometers. She describes the Spinsolve’s use and users’ reactions to using it:
Now all students run their own NMR spectra. They mainly run 1H spectra from their synthesis products. If they are interested, they can also run other spectra (13C and 2D-experiments). Our motivation for using Magritek Spinsolve is to teach our students NMR spectroscopy as a tool to analyze the structures of their synthesis products. The students can also use NMR in addition to IR to solve the unknown organic compounds when they do their qualitative organic analysis work.
The students like to use the Spinsolve spectrometer as it is fast and quite easy to use. For teaching staff, one advantage of the Spinsolve is that it requires very little maintenance and does not require cryogens nor require much bench space. The level of success is reflected in that even some of our researchers have used the Magritek system to look at their reaction products.
Professor Cyrille Monnereau
Professor of Chemistry at ENS de Lyon, France
we are indeed very happy with the experience we’ve had so far with your instrument. We tried to use it as much as we can in our training, and we had the opportunity to offer access to the machine to other students (from highschools and french “preparatory classes” ie 1st-2nd year of academic studies).The ENS Lyon offers a specific training to its students who envision becoming future university teachers. This training involves a lot of laboratory classes. During these classes, our students are requested to present and discuss a variety of synthetic and analytical techniques in front of a jury. So far, for obvious technical reasons, NMR was not routinely available for such presentations. The purchase of the Spinsolve system has been a great improvment in this framework. It has opened new perspectives in the construction of these presentations, and consistently enriched the ensuing discussions (about the nature of the magnet, the information we get from the spectrum regarding the nature and purity o fthe sample, and the main spectral differences obtained as compared with the larger fields cryomagnet spectrometers they have been used to during their internships in research laboratories) . The fact that it can be purchased as an affordable price and virtually no maintenance cost is ideally suited for a teaching department, were running costs are sometimes difficult to handle!
Dr Michael King
Chair of the Department of Chemistry at GWU
Dr Michael King is Chair of the Department of Chemistry at GWU, a private, coeducational research university located in Washington DC. The Department has two benchtop Spinsolve NMR spectrometers from Magritek for the physical/analytical chemistry and organic chemistry laboratories. In Dr King’s class, it is used for quantitative organic analysis. The experiments performed by his students utilize the basic 1D proton mode; loading samples, obtaining spectra and then use the MNova software to clean up and analyze the resultant data. Every year about 160 students at GWU take this class, with each practical lab session having around 14 students. In the lab class each student is provided with solid and liquid unknowns and they have to determine from spectroscopy (NMR, IR) the structure of both.
“What I like about the Spinsolve and about the software is the high throughput.”
Commenting on why he likes the Spinsolve for teaching, Dr King says, ”What I like about the Spinsolve and about the software is the high throughput. Obtaining the spectrum takes only a few minutes – less time than making the solution and putting it into the NMR tube. Place the sample tube in the instrument; then run a few scans, we typically do 16, and the students have a high quality spectrum. In terms of preparation we just run a short few minute shim at the start of lab session and it’s good for the rest of the day.”
Dr Vania De Paoli
Professor in the Department of Chemistry at Cleveland State University, Ohio
Dr Vania De Paoli is an associate college lecturer in the Department of Chemistry at Cleveland State University in Ohio. Prior to investing in the Magritek benchtop NMR spectrometer, students‘ practical options were limited to the measurement of melting points and refractive index. Old gas chromatographs were so old, they were no longer functional. Students were not experiencing anything close to life in a modern organic chemistry laboratory. As Dr De Paoli says, the Spinsolve has changed this position immensely. “It is a small system, portable and lightweight. It is quickly ready to use allowing the students to have a real NMR analysis experience (they prepare the samples in standard NMR tubes, add the solvent and record the spectra in similar ways to a research grade NMR). The spectra are of good quality. The software is friendly and, overall, Spinsolve is readily affordable.”
“The spectra are of good quality. The software is friendly and, overall, Spinsolve is readily affordable.”
See the blog post here.
Dr Harald Baumgartner
Coordinator of Evening Chemistry Classes
HTBLA Wels is a higher technical vocational college of chemistry in Austria. Here, Dr Harald Baumgartner is responsible for the instrumental analytical laboratory. NMR has been part of the curriculum for some years. However, this was through a very old 1H-60 MHz NMR. New instruments usually require fillings of expensive liquid helium for cooling the magnet. Dr Baumgartner says “Compared to the old 60 MHz spectrometer, the Magritek Spinsolve benchtop spectrometer is so much easier to use. It is software-based so collecting and processing data is quite straightforward. As well as 1H spectra, our Spinsolve allows us to measure more complex spectra including 13C-spectra. Even 2-dimensional experiments are now available to the students.”
“As well as 1H spectra, our Spinsolve allows us to measure more complex spectra including 13C-spectra.”
Dr Maria Vogt
Professor of Chemistry at Bloomfield College
Dr Maria Vogt is Professor of Chemistry at Bloomfield College, an undergraduate college in New Jersey. “NMR is essential at many levels of chemistry. It is essential in graduate school and industries such as foods and pharmaceuticals. Providing a foundation in the analysis of simple samples by NMR at the undergraduate level will help prepare my students for the interpretation of the much more complex spectra of more complex molecules. The more hands-on experiences the kids get as undergraduates, the better they are prepared for further studies and/or the workplace.”
“The more hands-on experiences the kids get as undergraduates, the better they are prepared for further studies and/or the workplace.”
Purchase costs, prohibitive maintenance bills and complex operating conditions all made the thoughts of obtaining an NMR for undergraduates all but impossible. As she says, “For many years, no one was interested in manufacturing a simple NMR for undergraduate student use. It was all about the big-bucks systems. In recent years, however, I became aware of three or four such instruments becoming available. I looked into them but, quite frankly, was less than thrilled with their performance until Magritek came into the picture. Magritek’s Spinsolve is by far the easiest instrument to use. It is also extremely fast, with an excellent spectrum generated and printed out in a minute or two. The software is intuitive. Over my many years in research and teaching laboratories, I have seen instruments get more and more complex with even more complex software. These instruments are very powerful and can do a lot of stuff. However, they are less than user-friendly. First and foremost, I am interested in teaching my students as much as possible. I am not big on demos. I want the kids to run their own spectra and then analyze the results. Lab work should be fun. Generating and analyzing your own spectrum is a lot of fun. Most students really don’t like solving puzzles. However, I must say that they certainly enjoyed their experiences with the Spinsolve.”
“Magritek’s Spinsolve is by far the easiest instrument to use. It is also extremely fast, with an excellent spectrum generated and printed out in a minute or two.”
See the blog post here.
Dr Kaveh Azimi
Chairman of the Chemistry Department at Tarrant County College
Chemistry Department Chairman, Dr Kaveh Azimi, and staff, are enthusiastic about their decision. “Faculty selected Spinsolve spectrometer for many reasons. Its compact size is ideal for a teaching laboratory where space is at a premium. Maintenance free operation thanks to the permanent magnet design means there is no need for cryogen fills saving valuable resources. The simplicity of sample preparation and the fact that the system uses standard 5 mm NMR sample tubes make this an ideal instrument for a teaching lab. The quality of spectra is excellent and to have the option of a 13C upgrade increases the value of this initial investment.”
“We were “magnetized” by Spinsolve’s simplicity of operation and the superior quality of spectral output during the hands-on instrument demonstration. The Spinsolve took us for a surprising spin!”
Staff said “We were “magnetized” by Spinsolve’s simplicity of operation and the superior quality of spectral output during the hands-on instrument demonstration (high signal to noise and good peak resolution). The Spinsolve took us for a surprising spin!”
Dr Paul Wiget
Assistant Professor of Chemistry and Biochemistry Howard School of Arts and Sciences at Samford University, Birmingham
Dr Paul Wiget says “the greatest benefit of the system is its ease of use and low-level of training for student operation. We are also very fond of no longer needing an air source for spinning. The instrument is very fast and reliable compared to the old, larger, 60 MHz instrument we had. The requirement of consistent spin and the finicky nature of the software made the instrument less practical for student use, and very challenging for research purposes.”
“The greatest benefit of the system is its ease of use and low-level of training for student operation.”
“With the simultaneous 19F and 1H “nested” monitoring scripts, we can get reinforcing data by monitoring the reaction progress via two nuclei instead of just one. Additionally, when the dispersion issue arises during that experiment, we no longer have to abandon the more substituted alcohols because we can simply monitor the reaction via the 19F spectra.”
See the blog post here.
Assistant Professor of Chemistry at the College of Humanities and Sciences at Virginia Commonwealth University
Meredith Moses teaches a hands-on approach: “We use the NMR so that the students know and understand about NMR. If they go to grad school or industry, they need to be familiar with it. Also, they are expected to be able to analyze spectra for their second semester (lecture) final exam. I like them to produce spectra of their own compounds so they know if they got the right product or not. Some instructors just hand out spectra of one groups’ sample or use literature spectra, but that somewhat defeats the purpose of a practical course. Students should know how good THEIR product is.”
“I like [students] to produce spectra of their own compounds so they know if they got the right product or not. Some instructors just hand out spectra of one groups’ sample or use literature spectra, but that somewhat defeats the purpose of a practical course.”
See the blog post here.
Dr Jonathan Harburn
Lecturer of Medicinal Chemistry at the School of Medicine, Pharmacy and Health at Durham University
Dr Jonathan Harburn says “It has a small footprint; it is robust (student friendly); and is inexpensive in comparison to purchase and operating costs for a high field NMR. In the near future, we are going to place this in series with our Syrris Africa Microfluidic System for online NMR of new chemical entity library generation under flow conditions. This would be tandem with online LC/MS and would give the opportunity to have very fast synthesis and analysis of hundreds of compounds overnight. Setup of Magritek will be very easy in comparison to a high field, supercooled NMR.”
“It has a small footprint; it is robust (student friendly); and is inexpensive in comparison to purchase and operating costs for a high field NMR.”
See the blog post here.
Dr Alan Kenwright
Reader in the Department of Chemistry at Durham University
Dr Alan Kenwright: “being able to do measurements in the relatively low magnetic field (43 MHz) used by Magritek’s Spinsolve is a big advantage for us, particularly as the field it uses it not very different to the field actually used in many hospital MRI scanners.”
“…real time reaction monitoring using flow-through NMR techniques. This is not a new idea, but has previously been limited by the requirement to bring the reaction close to a large (static) and expensive NMR spectrometer. The small size of the Spinsolve means that we can mount it on a trolley with an uninterruptible power supply (UPS) and move it around the department – taking the spectrometer to the fume cupboard where the reaction is being carried out. Working with partners in industry, we are evaluating this in parallel with small footprint Mass Spectrometry to see what relevance this approach might have not just in the University laboratory but also in pilot plants and possibly even at production scale.”
“…the opportunities for students to get involved “hands-on” become less, so exposing them to a robust, simple instrument they can use themselves is a big plus.”
See the blog post here.
Dr Philip Sharpe
Lecturer of Chemistry in the School of Chemistry and Molecular Biosciences at the University of Queensland
“Students used to miss the link from theory to practical use. Now my groups can have a hands-on experience and understand the value of NMR to the synthetic chemist.
“Students used to miss the link from theory to practical use. Now my groups can have a hands-on experience and understand the value of NMR to the synthetic chemist. My second semester first-year students are taken through the basics of using Spinsolve. They make a product (paracetamol); run it on the NMR; acquire and process the data. Some of our more high achieving undergraduate students go a stage further with a six week research project where they are introduced to spectroscopy – IR, NMR and GC-MS. Each student is allowed to choose their own project. For example it could to study different reactions of benzaldehyde. They will analyse the products they synthesise to look at variations in substitution products. They are taught to use multiple techniques to confirm what they have made and the Spinsolve NMR machine is key to achieving this.”
“The versatility of Spinsolve is just great. It gives us the flexibility we need. Students and staff alike are very pleased to have access to it.”
See the blog post here.
Dr Marlon Jones
Professor of Chemistry in the Physical Science Department at Long Beach City College
“Previous to adding NMR capability, we introduced our students to IR spectroscopy and gas chromatography. When we saw the performance and price of the Spinsolve Benchtop NMR spectrometer from Magritek, we saw our opportunity to fulfil another of our goals. In particular, we were impressed with the durability and robustness of the machine. The range of different applications such as the 2D capability was most important when we came to make our purchase decision.”
“We were impressed with the durability and robustness of the machine. The range of different applications such as the 2D capability was most important when we came to make our purchase decision.”
See the blog post here.
Dr Teris van Beek
Wageningen University & Research, The Netherlands
Wageningen University & Research (WUR) is formed from the collaboration between Wageningen University and the Wageningen Research foundation. With the mission “to explore the potential of nature to improve the quality of life,” its staff and students work in the domain of healthy foods and living environments. Dr Teris van Beek is a Lecturer in the Department of Agrotechnology & Food Sciences. Among his responsibilities is the coordination of the undergraduate course in analytical chemistry where 220 molecular life sciences and biotechnology students are introduced to practical spectroscopy each year (UV, IR, MS, NMR, structure elucidation).
Students are taught the basics of NMR and in small groups work one afternoon with the Magritek 60 MHz NMR. They analyse the alcohol content of various liquors (quantitative NMR). In the same course, students also isolate some products (anethol, piperine, xanthorrhizol) and can then measure their own product to evaluate the identity and purity. In addition to the 60 MHz spectra, 400 MHz spectra are handed out. Immediately after this course, there is an organic synthesis course where students synthesize products. Again afterwards, they assess how successful their synthesis was. So they apply the knowledge acquired earlier.
In the 45 years before the acquisition of the Magritek, we used our research NMR (60 → 90 → 200 → 300 → 400 MHz) for teaching purposes. However since our move to a new lab and the sharp increase in the number of students, this has become logistically impossible. However we did not wish to lose the hands-on aspect and we like students to measure their own products. Therefore, we had to find an affordable alternative solution, i.e., an instrument with a low-field permanent magnet. Although the field strength poses a problem (we can no longer use certain compounds as the spectra are too complicated at 60 MHz), we chose 60 MHz. We tested four different table top low-field NMR instruments, and the Magritek came out best in terms of line width, sensitivity and ease of operation. The price was in the same range as the other instruments so we bought the Magritek. The Magritek also allows for all 2-dimensional (2D) NMR spectra but so far we have not used this option as the introductory course does not deal with 2D NMR. However it is possible, that we will use this option in one of the more advanced NMR courses.
Dr Joseph Hornack
Director of the Magnetic Resonance Laboratory at the Rochester Institute of Technology
“We chose the Spinsolve NMR for use in an Instrumental Analysis laboratory with 90 students (mostly chemical engineers). In addition to NMR, students get exposure to UV-Vis, fluorescence, AA, and IR spectroscopies. We wanted an NMR with a low operating cost which could be sited in the lab, and leave the students with a positive NMR experience. Just like with the Terranova from Magritek, the Spinsolve scores high points for ease of use, both in collecting and processing the data. Shimming is easy and does not need to be performed on each sample. The resolution is sufficient for students to easily analyze 1- and 2-D H spectra of small molecules. It can be used to measure spin-lattice and spin-spin relaxation times at 40 MHz that we cannot take with other instruments.”
“Just like with the Terranova from Magritek, the Spinsolve scores high points for ease of use, both in collecting and processing the data.”
See the blog post here.
Professor Magid Abou-Gharbia
Professor of Chemistry and Director of the Moulder Center for Drug Discovery Research in the School of Pharmacy at Temple University
“In order to ensure that our students are fully prepared to tackle the most pressing research problems of the next generation, we must ensure that they have the most advanced technology possible. The arrival of the Magritek Spinsolve in our institution is yet another example of Temple’s commitment to its students and high quality research.”
“Students, post-doctoral scientists, and visiting faculty have access to the benchtop Spinsolve NMR Spectrometer, allowing rapid, hands-on acquisition of critical program data, enabling them to solve complex research problems in a more efficient manner.”
“….the sleek benchtop design of this instrument will greatly simplify its integration into the existing laboratory space of the school of pharmacy. Its ease of use is expected to significantly enhance productivity of students and faculty, providing them with greater opportunity to pursue advanced research on a highly competitive level. Students, post-doctoral scientists, and visiting faculty have access to the benchtop Spinsolve NMR Spectrometer, allowing rapid, hands-on acquisition of critical program data, enabling them to solve complex research problems in a more efficient manner. The system will be a focal piece of the Moulder Center for Drug Discovery Research’s analytical technology suite.”
Dr Andrew York
Johnson Matthey Technology Centre, UK
Dr Andrew York is a Senior Principal Scientist at the Johnson Matthey Technology Centre at Sonning Common. Dr York’s group purchased the Magritek Spinsolve benchtop NMR spectrometer to characterize materials of importance to the businesses in the company. Describing why they use this technique, Dr York says:
The relaxometry technique in particular is very fast and can be used very easily in the laboratory to get information about our materials. This means we can develop quick and low cost measurements for control of materials going into processes.
Discussing the benefits of using Spinsolve, Dr York continued:
It is low cost, but also powerful and so far has allowed us to do many of the experiments we need to do. So if need be we can also do quick spectroscopy experiments. However, it is the Expert software that allows most of the real user flexibility. The continuing development of this software by Magritek helps us make the most of the machine in our very non-standard applications.
Dr Patrick Giraudeau
Associate Professor of Analytical Chemistry at the University of Nantes
We had the privilege to acquire in 2015 the first Magritek Spinsolve with a gradient coil. Since then, our experience with the Spinsolve has been extremely exciting and rewarding. The great performance of the hardware, in terms of stability and robustness, has made it possible to implement challenging NMR experiments such as multi-pulse solvent suppression methods, and ultrafast 2D NMR –probably one of the most hardware-demanding NMR experiments. We are applying these innovative methods in various fields, from the real-time and online monitoring of chemical reactions to the high-throughput screening of food matrices. I can confidently say that the Spinsolve has opened new research avenues in our lab, as well as new collaboration perspectives.
Professor Lee Cronin
Regius Chair of Chemistry in the School of Chemistry at the University of Glasgow
“We now use the Magritek Spinsolve in the ‘flow’ mode that we developed in my lab. For our work, this is important as it allows us to look at reaction dynamics. We can run entire reactions (no need for deuterated solvent) or look at things in real time; we can adjust reaction outcomes as a function of NMR. This makes for a very flexible system.”
“Despite the low field of the magnet, Spinsolve has remarkable sensitivity and stability.”
See the blog post here.
Dr Michael Maiwald
Head of Process Analytical Chemistry Division at the BAM Institute
“We were impressed with the spectra – the symmetrical line shape and narrow line width was achieved even in technical mixtures. This is due to the use of Halbach magnets. The stability we observed over a given period of time without preparing the instruments was extremely good. We have seen that the Spinsolve remains working in specification for as much as 48 h in a technical environment. Pre-magnetisation below the active region of the magnet is important to us for online measurements. As far as we see, the instrument meets this requirement.”
“We were impressed with the spectra – the symmetrical line shape and narrow line width was achieved even in technical mixtures.”
See the blog post here.
Dr Mario Killner
Institute of Chemistry at the University of Campinas
“This is the first time that our group has had access to NMR in our laboratories. For a long time, our research group has been working mostly with NIR spectroscopy and, most recently, with Terahertz spectroscopy to develop new methodologies applying chemometric tools. Now we’d like to implement the NMR spectroscopy (low-field) in our research starting with analysis of fuel. We believe that the benefits of using NMR will be on the speed of analysis (comparing to physical-chemicals essays for fuels, which are laborious and time consuming), the cost of analysis and the possibility of automation sometime in the future.”
“This is the first time that our group has had access to NMR in our laboratories.”
Dr Theo Dingemans
Professor of Chemistry and Aerospace Engineering at the Faculty of Aerospace Engineering at the Delft University of Technology
Dr Theo Dingemans: “we use NMR to understand the structure/product confirmation of organic small molecules and polymers. Sometimes we use it to follow progress of the reactions. We chose the Spinsolve system because it’s very easy to use. It requires no cryogens and very little maintenance. When we need to use the high resolution NMR system, this requires sign-up and is on the other side of campus. Now we can do chemistry in the lab: take a sample and analyse it immediately. It improves our productivity in the lab.”
“Now we can do chemistry in the lab: take a sample and analyse it immediately. It improves our productivity in the lab.”
See the blog post here.
Dr Jeroen Geuens
Member of the Centre of Expertise on Sustainable Chemistry (CESC) based in Antwerp at the Karel de Grote University College
“In teaching, our 2nd and 3rd year students (professional bachelor in chemistry) are using the Spinsolve during their lab sessions for organic chemistry. They synthesize organic molecules such as tertiary butyl chloride, aspirin, and isopentyl acetate. They purify their products and then analyze them using NMR and FTIR. In total, approximately 80 students are using the Spinsolve during the organic chemistry lab each year. For research, CESC is studying the valorization of organic waste streams. The standard treatment procedure for an unknown waste sample is accelerated solvent extraction (ASE) using solvents with different polarities. After the solvent is evaporated, the different fractions are analyzed by means of NMR, FTIR, and GC-MS. There are also three oleochemical projects running, i.e. projects concerning vegetable oils. For these projects, we implemented a method to determine the iodine value of an oil with the Spinsolve. The standard method to measure the iodine value implies a titration using the Hanus iodine solution which has to be prepared fresh. Moreover, a standard solution of Na2S2O3 is needed as well as glacial acetic acid which all takes considerable time. When using the Spinsolve, no solvents or chemicals are needed. The only thing you have to do is put the oil in a NMR tube, keep yourself busy for 21 minutes, and return to the apparatus for the result.”
“When using the Spinsolve, no solvents or chemicals are needed. The only thing you have to do is put the oil in a NMR tube, keep yourself busy for 21 minutes, and return to the apparatus for the result.”
See the blog post here.
Dr Peter Keizers
Centre for Health Protection at RIVM
Dr Peter Keizers is a scientist in the Centre for Health Protection at RIVM, the Dutch National Institute for Public Health and the Environment based in Bilthoven. As a chemist, he investigates (illegal) drugs, medical devices and other medicinal products. His group studies the composition of these products and specifically look for active pharmaceutical ingredients, preferably in a quantitative way.
In order to identify components in medicinal products, selective analytical methods are required. NMR spectroscopy is such a technique. Furthermore, NMR spectroscopy offers a direct way to quantify any of the components encountered without the need of a reference standard. Historically we have used and will continue to use high field NMR spectroscopy, various forms of vibration spectroscopy as well as mass spectrometry coupled to chromatographic systems.
Dr Keizers comments on the benefits of their using the Spinsolve 60.
“Compared to other spectroscopic methods, the Magritek benchtop NMR spectrometer yields spectra with relatively high information content directly related to molecular structure. This aspect is even strengthened by the option to monitor other nuclei than just 1H proton and the ability to perform 2D experiments. Compared to high field NMR spectrometers, the benchtop version is easy to use and maintain. It is also much more economic to run using standard NMR sample tubes and not requiring any cryogens.”
See the blog post here.
Professor Stephen Ley
Department of Chemistry, University of Cambridge
Professor Steven Ley’s laboratories are located in the Department of Chemistry at the University of Cambridge, where his research specialises in flow chemistry and organic synthesis. Dr Batool Omer worked in the Ley Group as a Postdoctoral Research Associate prior to taking up her current position at GSK. She has played a leading role in the integration of the Magritek Spinsolve into the flow research work carried out in Cambridge. This is what Dr Omer says about the Spinsolve:
“The main motivation is due to the inherent versatility of NMR spectroscopy which enables simultaneous structure identification and quantification.This feature makes it both a useful and indispensable tool in chemical synthesis. There are other complementary techniques including ReactIR. After evaluating a number of benchtop NMR systems, it is my opinion that the Magritek system gives the most potential. Simply it gives us the ability to integrate it into a flow process easily; it has the options of different flow cells; it has fast acquisition times and, most importantly, the sensitivity. I find the Spinsolve to be much more enhanced compared to others on the market. Furthermore, since I joined industry, I have noticed that a number of industries regard the Magritek system as a highly useful PAT (process analytical technology) tool.”
See the blog post here.