Dr Jonathan Harburn is a Lecturer in Medicinal Chemistry in the Wolfson Research Institute located in the School of Medicine, Pharmacy and Health at Durham University. Working together with Drs Stuart Cockerill and Jonathan Sellars, Dr Harburn’s research goals are to create clinical drug candidates for the treatment of viruses, bacteria and cancer.
In their research, recent progress has focussed repurposing novel fluorinated drug fragments on known drug scaffolds to develop hit identification. 19F NMR using Spinsolve is one of the most useful tools in confirming fluorinated fragment incorporation with spectra run in 3 minutes. Also, 1H NMR is routinely carried out for identification before further spectral data is acquired on higher field NMR.
Alistair Paterson, a Level 2 MPharm student at Durham University, uses Spinsolve to evaluate his sulfathiazole sample
Dr Maria Vogt is Professor of Chemistry at Bloomfield College in New Jersey where she teaches lectures and runs labs in Organic Chemistry and Biochemistry. Having had a prior research career and publishing more than 45 papers, Dr Vogt now devotes her efforts to prepare students for the “real world” by exposing them to as many hands-on and instrumental skills as possible prior to graduation. She encourages the development of problem-solving skills. NMR spectra are used as “puzzles” through which the students are pushed to use their brain to figure out unknown samples in their practical classes.
Dr Vogt is enthusiastic about introducing practical hands-on NMR to her students “Analyzing an NMR spectrum is just plain fun! NMR is essential at many levels of chemistry. It is essential in graduate school and industries such as foods and pharmaceuticals. Providing a foundation in the analysis of simple samples by NMR at the undergraduate level will help prepare my students for the interpretation of the much more complex spectra of more complex molecules.”
Undergraduate chemistry major, Tytianna Drew, uses the Magritek Spinsolve benchtop NMR spectrometer in her organic chemistry classes. Her college laboratory experience has earned her a summer internship at global biopharmaceutical company, Celgene Corporation, headquartered in New Jersey.(more…)
In this video Dr. Philip Sharpe talks about how he uses the Spinsolve Benchtop NMR spectrometer in the undergraduate teaching and research labs at The University of Queensland. An interesting feature of Philip’s setup is his mounting of the Spinsolve benchtop NMR spectrometer on a trolley with an uninterruptible power supply – enabling easy transport among the various student laboratories, with immediate availability on arrival.
Magritek reports on the use of their Spinsolve Benchtop NMR system at the BAM Federal Institute for Materials Research and Testing.
The BAM Federal Institute for Materials Research and Testing operates under the guideline “Safety in Technology and Chemistry.” For the field of analytical chemistry, this defines tasks with the main emphasis on development and provision of certified reference materials (CRM), development and validation of complex analytical methods, methods for the assessment of analytical laboratories, and establishing and fostering national and international networks committed to the assurance of quality, reliability and comparability in analytical chemistry. The focus of Division 1.4 Process Analytical Technology (PAT) is the development and application of PAT technologies. This includes development and validation of analytical online and at-line methods.
Dr Alan Kenwright is Reader in Spectroscopy and Manager of the solution-state NMR facility in the Chemistry Department at Durham University. His personal research is focussed on developing and using NMR techniques to solve a range of chemical problems. In choosing to use Magritek’s Spinsolve, Dr Kenwright anticipates it will allow the extension of his work in various areas in ways that he could not otherwise. He plans to use the equipment initially in three areas:
Dr Nicola Rogers is a post doc in the Kenwright group using the Magritek Spinsolve to make relaxation measurements on lanthanide complexes at Durham University. For ease of use, it is mounted on a trolley making it easy to move from lab to lab.
“The first application is in looking at lanthanide complexes of the sort used as contrast agents for MRI” … “being able to do measurements in the relatively low magnetic field (43 MHz) used by Magritek’s Spinsolve is a big advantage for us, particularly as the field it uses it not very different to the field actually used in many hospital MRI scanners. These measurements using the Spinsolve are just starting to appear in the literature.” (reference given at the end of this blog post)
Dr. Paul Wiget is an assistant professor of chemistry at Samford University in Birmingham, Alabama. He chose the Spinsolve Carbon benchtop NMR spectrometer to support both his research work and for teaching. For Dr. Wiget the ability to perform 13C, DEPT, HSQC, HMBC experiments was most important. He also saw the scripting function as extraordinarily helpful as it would enable the running of a HSQC experiment and followed by an HMBC routine allowing extraction from the 13C data overnight even when measuring dilute samples.
Magritek reports on reaction monitoring research using the Spinsolve benchtop NMR system in the Cronin Group at the University of Glasgow
Professor Lee Cronin holds the Regius Chair of Chemistry at the University of Glasgow. Research in the Cronin Group is motivated by the fascination for complex chemical systems and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks. They are developing a new approach to the chemical sciences which they call Chemical Cybernetics. This combines robotics, algorithms, flow chemistry and reaction programming. Over a number of years, Professor Cronin and his colleagues have used use a lot of integrated techniques to explore chemical reaction systems. For example, one networked flow and flow systems including mass spectrometry, IR, UV and NMR.
Cleveland State University in Ohio is developing into one of the best urban universities in the nation. Investment at the ground roots graduate level is illustrated by the recent purchase of benchtop NMR spectrometry to offer students hands-on experience of the latest in scientific instrumentation.
Dr Vania De Paoli is an associate college lecturer in the Department of Chemistry where she is leading a program to create a solid environment for teaching Organic Chemistry. Prior to investing in the Magritek benchtop NMR spectrometer, students‘ practical options were limited to the measurement of melting points and refractive index. Students were not experiencing anything close to life in a modern organic chemistry laboratory.
As Dr De Paoli says, the Spinsolve has changed this position immensely. “It is a small system, portable and lightweight. It is quickly ready to use allowing the students to have a real NMR analysis experience (they prepare the samples in standard NMR tubes, add the solvent and record the spectra in similar ways to a research grade NMR). The spectra are of good quality. The software is friendly and, overall, Spinsolve is readily affordable.”
Ms Lucy (Meredith) Moses is a member of the Faculty in the Chemistry Department and is an Assistant Professor at Virginia Commonwealth University (VCU). She teaches a hands-on approach to enable students to understand and run analytical techniques rather than to rely solely on text books and second-hand spectra. Her group is using the Magritek Spinsolve benchtop NMR spectrometer.
Magritek reports on the use of their Spinsolve Benchtop NMR system in the undergraduate teaching program at Long Beach City College.
Dr Marlon Jones is an Instructor of Chemistry in the Physical Science Department at Long Beach City College (LBCC). The College has served the community for more than eighty years through exceptional educational and student support services opportunities to help them succeed including moving on to full time university education. His teaching goals for the Organic Chemistry course at LBCC are to ensure that students have a fundamental understanding of the basic aspects of NMR and have the ability to interpret basic NMR spectral data.