Magritek is really excited to be present at SMASH 2017 in Baveno, Italy from 17th – 20th September 2017 .We really look forward to meeting you. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.
The Small Molecule NMR Conference will take place at the Grand Hotel Dino in Baveno – Corso Giuseppe Garibaldi, 20, 28831 Baveno VB, Italy.
Professor Steven Ley’s laboratories are located in the Department of Chemistry at the University of Cambridge. Their research specialises in flow chemistry and organic synthesis. They are renowned for collaborations with academic and industrial partners. Précising their work, Steve says
“Complex synthesis remains a challenging occupation requiring an exceptional level of experimental skill, extensive knowledge of both mechanistic and molecular reactivity, and a bold, inventive, and creative spirit. It is the combination of these qualities that transforms the synthesis process from one of simple logistics to an art form.”
One of the advanced features of the Spinsolve 80 is the ability to run a Multiplicity Edited HSQC, also known as HSQC-ME. This powerful 2D NMR sequence has proton in the horizontal (f2) axis and carbon in the vertical (f1) axis. The peaks appear where a proton is connected to a carbon atom. Additional information about “multiplicity” is given by the sign of the peak, just like in a DEPT experiment. Positive peaks (red) are either CH or CH3, while negative peaks (blue) are from CH2. This additional information really helps with correct peak assignment.
The example below is from an HSQC-ME experiment run on a sample of Quinine and shows all the peaks uniquely resolved and assigned.
Dr Irosha Nawarathne is an Assistant Professor in the Chemistry Department at Lyon College, a selective liberal arts institution in rural Arkansas. Her work bridges biomedical research to teaching students the practical use of instrumentation to prepare them for employment and the challenges of the chemical industry. She summarizes her experience with the Spinsolve, which was added to the Chemistry Department in 2015:
Spinsolve has become the most popular among faculty and students of our chemistry program. It is used in organic chemistry, instrumental analysis, and advanced inorganic chemistry laboratories. We plan to extend the usage to other areas too. Students have become very interested in the concept of NMR because of this instrument. Their knowledge of NMR is improved tremendously after the incorporation of Spinsolve in the chemistry program. It is easy to operate, provides quick analysis, and requires very low maintenance. Spinsolve is definitely the best fit for a small college like ours. We formerly had a cryogenic NMR spectrometer at Lyon but the chemistry program has not been able to maintain the instrument in the long term. Spinsolve is low cost and its low maintenance is key for its great fit to Lyon chemistry program. It is also used in recruiting keen students as they get really excited about the instrument and its capabilities during frequent campus tours.
Silicon is one of the most widespread elements in the natural world and, as such, this makes it a very interesting and useful element to study using NMR. Over the past few decades, a wide range of silicon-containing compounds have been investigated using both solid- and liquid-state NMR techniques. For example, siloxane polymers, which are extensively used in biomedical and cosmetic applications, have been extensively studied by NMR to understand their structure and individual building blocks. Similarly, the structure of silicates, zeolites and other materials have been studied by silicon NMR. Silicon NMR has been shown to be a powerful tool for the determination of active end groups, cross-linking moieties and polymer sequencing.
Magritek is really excited to be present at SCS Fall Meeting in Bern, Switzerland from 21st – 22nd August – 2017 .We really look forward to meeting you on the Booth 14. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.
Benchtop NMR systems have become popular analytical lab instruments in the last years. With the recent launch of the Spinsolve Ultra the magnetic field homogeneity has been improved to match a lines shape that is comparable to superconducting magnets, while the brand new Spinsolve 80 pushes the limits in chemical shift spreading and sensitivity for a benchtop system.
The conference will take place on the University of Bern ( von roll area ), Fabrikstrasse 6, B6: lectures Fabrikstrasse 8, B8, 3012 Bern, Switzerland.
Did you miss our recent webinar ? No problem, just click the red button below to stream a replay of the webinar held on 27th June 2017: Practical use of 13C Benchtop NMR Spectroscopy in an Undergraduate Laboratory
Dr Peter Keizers is a scientist in the Centre for Health Protection at RIVM, the Dutch National Institute for Public Health and the Environment based in Bilthoven. As a chemist, he investigates (illegal) drugs, medical devices and other medicinal products. His group studies the composition of these products and specifically look for active pharmaceutical ingredients, preferably in a quantitative way.