Malvern, PA, USA, 4th December 2018: Magritek announces that it has been awarded a major contract by the US Drug Enforcement Administration (DEA) for two Spinsolve 80 Carbon benchtop NMR spectrometers. The purchase was made through a competitive award process and will allow DEA laboratories in Virginia and California to utilize the latest benchtop NMR technology to assist in forensic analysis applications.
Speaking about this prestigious award, Magritek Inc’s CEO, Dr Hector Robert, says
“We are very excited to be awarded this contract by the DEA. The selection of the 80 MHz Spinsolve instrument with 1H, 19F and 13C nuclei provides a versatile system suited to the analysis of many substances studied in forensic science. The systems are supplied with autosamplers which enable the measurement of multiple samples with an automated and efficient workflow.”
There are two naturally occurring NMR active nuclei of Boron, 11B (80.1%) and 10B (19.9%). Both nuclei are quadrupolar with spin of greater than ½. 11B has a spin of 3/2 and 10B is spin 3. In terms of sensitivity, 11B is the better nucleus to use as it has a higher natural abundance, a higher gyromagnetic ration, and a lower quadrupole moment. A Spinsolve benchtop NMR spectrometer with a proton frequency of 60 MHz can be configured to measure the 11B NMR signal which has a frequency of 19.2 MHz.
The 11B NMR spectrum of a 0.23 M solution Sodium tertraphenylborate in MeOH-d4 is shown below. The first spectrum shows the excellent sensitivity of Spinsolve using just 8 scans to acquire a spectrum in only 16 seconds.
In my first two posts on using 1D and 2D NMR methods to assign the peaks of quinine (Figure 1), I looked at the 1H and 13C spectra.
Figure 1. Structure of quinine
In this post, I’m moving on to look at the 1H-13C HSQC spectrum. It’s worth spending a brief moment recapping what HSQC is all about and what info it gives you. In a nutshell, the HSQC experiment correlates proton and carbon chemical shifts over one chemical bond. Another way to put this is that a cross-peak in an HSQC spectrum says, “The proton with this chemical shift is directly attached to the carbon with that chemical shift”. By convention, HSQC spectra are presented with 1H shifts along the horizontal axis and 13C shifts along the vertical axis.
Some variants of HSQC also encode into the phases of the cross-peaks additional information about how many hydrogen atoms are attached to each carbon atom. This is sometimes referred to as multiplicity or DEPT editing. In the multiplicity-edited HSQC spectrum, it is conventional for the CH and CH3 groups to have positive phase, and the CH2 groups to have negative phase, just as in a DEPT-135 spectrum. Figure 2 shows the multiplicity-edited HSQC (“HSQC-ME”) spectrum of our 400 mM quinine sample. The CH2 signals are shown in blue and the CH and CH3 signals in red.
Magritek is really excited to be at ISRANALYTICA 2019 in Tel-Aviv, Israel from 22-23 January 2019. Our distributor ISI and the Magritek team will have a live, working Spinsolve Benchtop NMR and our fabulous applications and support team will be there to answer all your benchtop NMR spectroscopy questions.
Please, don’t forget to assist to the Magritek session on the day 2 / 23 January, 16:20 Hr at the Hall B.
Magritek is participating in the FORUM LABO in 26-27-28 March 2019 in Paris – France. You’ll get a chance to meet us, learn about our company and we’ll get you acquainted with Spinsolve – high-performance benchtop NMR spectrometer that offers impressive sensitivity and resolution, it is robust and easy to use. We are looking forward to seeing you at this conference !!!(more…)
The benchtop NMR business is significantly expanding and therefore Magritek is seeking for an Application Scientist based in our European Headquarters in Aachen, Germany, capable of making a significant contribution to the future success of our company.
CSI in Mosbach ? Forensische Toxikologie – nicht so wie im Fernsehen
Magritek is participating in the XXI Mosbacher Symposium in Forensic Toxicology in Mosbach – Germany. You’ll get a chance to meet us, learn about our company and we’ll get you acquainted with Spinsolve – high-performance benchtop NMR spectrometer that offers impressive sensitivity and resolution, it is robust and easy to use. We are looking forward to seeing you at this conference !!!
The Symposium will include Trends in der Forensischen Chemie und Toxikologie
About Quantitative NMR Methods for Reaction and Process Monitoring Conference in Kaiserslautern
The NMRPM symposium brings scientists who apply NMR methods for reaction and process monitoring in academia and industries together, with the goal to narrow the gap between what is achieved with NMR techniques under ideal conditions and what is possible under conditions relevant to industrial applications. For example, we will discuss the challenges that arise during quantitative investigations of processes in complex multicomponent mixtures in an industrial environment using NMR spectroscopy
The group of Professor Lee Cronin at the University of Glasgow has combined machine learning with a chemical reaction system to speed up the discovery of new chemical reactions, which is an inherently unpredictable and time consuming process. This new approach of an Organic Synthesis Robot uses a Spinsolve Benchtop NMR spectrometer as an integral component. Their work has just been published in the prestigious journal Nature: J. M. Granda, L. Donina, V. Dragone, D.-L. Long and L. Cronin, Nature559, 377–381 (2018), DOI: 10.1038/s41586-018-0307-8
Photograph of the chemical robot
The photo shows the impressive setup of the chemical robot with 27 pumps, valves and six reactors, as well as NMR, IR and MS spectrometers for real-time analytics.