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61st ENC – Maryland, Baltimore – March 8 – 13, 2020

February 6th, 2020, by

Magritek is delighted to announce its participation at the 61st ENC (Experimental Nuclear Magnetic Resonance Conference) which is to be held at Hilton Baltimore Inner Harbor, Stone Suite, Baltimore, Maryland, MD.

We look forward to seeing you there for a chat with our scientists about the capabilities and applications of our 80MHz Spinsolve Benchtop NMR system which we will have for you to see in action.

VENUE:
Hilton Baltimore Inner Harbor Hotel
401 W Pratt St, Baltimore, MD 21201, USA

PITTCON 2020 Conference – Chicago, Illinois – March 1 – 5, 2020

February 6th, 2020, by

Come and meet us at PITTCON 2020 in Chicago, Illinois where our Magritek representatives will be happy to have a one-on-one chat with you at our booth #1143.  Our onsite scientists can discuss with you the capabilities and applications of Spinsolve Benchtop NMR system where you will be able to see our 80MHz Spinsolve with Autosampler in action.

We will also be conducting a presentation at Pittcon on Applications of Benchtop NMR in Manufacturing and Research, March 3 @ 9:30am, Room W184A

We look forward to seeing you at this event.

VENUE:
McCormick Place – West Hall
2301 South Lake Shore Drive, Chicago, IL 60616, USA

Benchtop NMR characterisation of diethyl phthalate containing land leeches repellent

June 18th, 2019, by

In Vietnam, for the observation of animals in the jungle of the national park of Cat Tien (and in other parts of the country and in Asia), the rangers give the tourists leech socks and a repellent cream for land leeches to put on the socks. Land leeches are terrestrial blood-sucking worm-like parasites. Reading the cream container, I noticed that it contains diethyl phthalate (DEP). Out of curiosity, I dissolved some of the cream in CDCl3 and acquired a NMR spectrum with the Spinsolve 80 MHz benchtop NMR spectrometer.

The 1D 1H spectrum confirms that the cream is mainly composed of diethyl phthalate (Fig. 1, a). A zoom of the spectrum (Fig. 1, b) shows the presence of some additional compounds overlapping with the 13C satellite peaks of DEP (0.55% of the main peaks). To simplify the identification of the additional compounds present in the cream I acquired a 1D 1H spectrum using the carbon decoupling protocol available in the Spinsolve software (Fig. 1, c). This method removes the satellites from the spectra making it possible to detect compounds dissolved at concentration smaller than 1% with respect to DEP.

Typical excipients used in such creams are fatty acid mixtures from butter and/or oils, glycerol/glycine, alcohol (multiplet ~ 3.5 ppm, CH2-OH) and PEG based compounds (peak ~ 3.6 ppm) and even perfume(s).

In our case, the fatty acid peaks are easily recognized. The terminal methyl of fatty acids is observed in region F around 0.8 ppm, the aliphatic chain in region E and probably under the CH3 of DEP, and the olefinic protons of saturated fatty acids around 5.2 ppm in the region A. As no signal is observed around 2.8 ppm, the saturated fatty acids present in the cream are mono unsaturated. The singlet at 2.47 ppm (singlet C) could be a residual solvent like DMSO or 1,3-dioxan, common solvents contaminating cosmetic cream. To check this hypothesis, ~ 2 µL of solvent was added. If the cream contains the solvent, the integral of peak C would increase, but in our case new peaks were observed (data not show). Region B correspond to a CH3 group next to a (mono or di) substituted aliphatic. The area D could be a triplet with a J coupling of 7 Hz. These peaks probably belong to a perfume, where the additional peaks of the perfume molecule overlap with peaks of DEP.

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43rd Organic Process Research and Development (OPRD) – Clearwater, Florida – March 9 – 11, 2020

February 6th, 2020, by

Magritek is delighted to announce its participation at the 43rd Organic Process Research and Development (OPRD) in Clearwater, Florida on March 9 – 11, 2020.

We look forward to seeing you there for a chat with our representatives about the capabilities and applications of our Spinsolve Benchtop NMR systems.

VENUE:
Sheraton Sand Key Resort
1160 Gulf Boulevard, Clearwater Beach, Florida 33767, USA

AAFS Annual Scientific Meeting – Anaheim, California – February 17 – 22, 2020

February 6th, 2020, by

Magritek is delighted to announce its participation at the American Academy of Forensic Sciences (AAFS) Annual Scientific Meeting – Anaheim, California, February 17 – 22, 2020.

Please stop at our Booth#223 and talk to our scientists about the capabilities and applications of the Spinsolve Benchtop NMR system.

We look forward to seeing you at this event.

VENUE:
Anaheim Convention Center
200 South Anaheim Boulevard, Anaheim, California 92805, USA

Spring ACS in Philadelphia, PA – March 22 – 26, 2020

February 6th, 2020, by

Join Magritek at the National Spring ACS in Philadelphia, in PA.  Please stop by our booth #824 and talk to our scientists about the capabilities and applications of the live 80MHz with Autosampler Spinsolve Benchtop NMR system.

We look forward to seeing you at this event.

VENUE:
Pennsylvania Convention Center
1101 Arch Street, Philadelphia, PA 19107, USA

How to Evaluate a Benchtop NMR Instrument’s Technical Performance Part 4: 13C Sensitivity

July 17th, 2019, by

After 1H, 13C is easily the next most important nuclide in the NMR periodic table; 13C measurements can provide a wealth of valuable structural info. Unfortunately, with a receptivity that is around 5,500 smaller than that of 1H, 13C is a much less sensitive nuclide. This lower sensitivity demands the maximum performance from the NMR spectrometer to keep the measurement times and sample concentration within practical limits. Since 13C NMR has the reputation to be challenging even for high field spectrometers, people tend to think that only overnight experiments can be performed on bench top systems. In the first example below we want to show you that even at frequencies like 43, 60 or 80 MHz high quality 13C spectra can be acquired in a single scan. If your goal is to teach the principles of 13C NMR to students, it is worth knowing that good 13C NMR spectra can be acquired on concentrated organic liquid samples in just under a minute. Moreover students can collect a whole set of powerful multidimensional heteronuclear experiments in well under an hour. The spectrum below of neat propylbenzoate could serve as a useful example for teaching 13C NMR in an educational environment.

Figure1: 1D 13C NMR spectra of neat Propylbenzoate acquired with a single scan (blue), 4 scans (green) and 16 (red) scans totalling 5, 20 and 80 seconds of acquisition time respectively.

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