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LAB Innovation in Birmingham – United Kingdom on October 31-01 November, 2018

August 16th, 2018, by

Magritek is participating in the leading process chemistry conference LAB Innovation  in Birmingham-United Kingdom. Drop by our booth # C10! You’ll get a chance to meet us, learn about our company and we’ll get you acquainted with Spinsolve – high performance benchtop NMR spectrometer that offers impressive sensitivity and resolution, it is robust and easy to use. We are looking forward to seeing you at this conference !!!

Robot Chemist publication in Nature includes a Spinsolve benchtop NMR spectrometer

July 24th, 2018, by

The group of Professor Lee Cronin at the University of Glasgow has combined machine learning with a chemical reaction system to speed up the discovery of new chemical reactions, which is an inherently unpredictable and time consuming process. This new approach of an Organic Synthesis Robot uses a Spinsolve Benchtop NMR spectrometer as an integral component. Their work has just been published in the prestigious journal Nature: J. M. Granda, L. Donina, V. Dragone, D.-L. Long and L. Cronin, Nature 559, 377–381 (2018), DOI: 10.1038/s41586-018-0307-8

Photograph of the chemical robot

The photo shows the impressive setup of the chemical robot with 27 pumps, valves and six reactors, as well as NMR, IR and MS spectrometers for real-time analytics.

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Quantification of hydrocarbon content in water analysis at ppm level using benchtop NMR

June 20th, 2018, by

The permitted hydrocarbon content of discharged water from offshore oil and gas exploration is becoming increasingly limited by more stringent legislation. This creates the demand for measurement methods that are sensitive enough to detect contaminants at ppm level, but also compact and robust to field conditions. The group of Professor Mike Johns at the University of Western Australia in Perth has developed a benchtop NMR method to quantify the hydrocarbon content in water at the ppm level.


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1H and 13C Peak Assignments of Quinine Using 1D and 2D NMR Methods: Part 1

June 7th, 2018, by

Assigning peaks in the NMR spectrum is a fundamental part of structure verification. Depending on a variety of factors including the size and complexity of the molecule, and the field strength the NMR data are collected at, this can be a straightforward exercise or an extremely challenging one! For example, in the case of a fairly simple compound like lidocaine, it is relatively easy to assign all of the peaks directly in the 1H spectrum using a 43 MHz benchtop NMR spectrometer. However, as a compound’s molecular weight increases so the spectra tend to become more complex, with more resonances and, inevitably, more signal overlap. Assigning the peaks thus becomes significantly more challenging, which is where collecting 2D NMR spectra can help with completing the assignments.

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ILMAC 2018 in Lausanne – Switzerland on October 3 – 4, 2018

August 16th, 2018, by

Magritek is delighted to announce its participation in ILMAC 2018 in Lausanne, Switzerland. Please stop by at the booth #C18 and talk to our scientists about the capabilities and applications of Spinsolve Benchtop NMR system. You’ll be able to witness its exceptional performance and see how easy it is to operate. We are looking forward to seeing you at this event!

Date
Wednesday, the 3rd to Tuesday, the 4th October 2018

Location
Expo Beaulieu Lausanne, hall 7
Avenue Bergières 10
1004 Lausanne

Opening times
9 a.m. to 5 p.m.

1H and 13C Peak Assignments of Quinine Using 1D and 2D NMR Methods (Part 3)

July 15th, 2018, by

In my first two posts on using 1D and 2D NMR methods to assign the peaks of quinine (Figure 1), I looked at the 1H and 13C spectra.

 

Figure 1. Structure of quinine

 

In this post, I’m moving on to look at the 1H-13C HSQC spectrum. It’s worth spending a brief moment recapping what HSQC is all about and what info it gives you. In a nutshell, the HSQC experiment correlates proton and carbon chemical shifts over one chemical bond. Another way to put this is that a cross-peak in an HSQC spectrum says, “The proton with this chemical shift is directly attached to the carbon with that chemical shift”. By convention, HSQC spectra are presented with 1H shifts along the horizontal axis and 13C shifts along the vertical axis.

Some variants of HSQC also encode into the phases of the cross-peaks additional information about how many hydrogen atoms are attached to each carbon atom. This is sometimes referred to as multiplicity or DEPT editing. In the multiplicity-edited HSQC spectrum, it is conventional for the CH and CH3 groups to have positive phase, and the CH2 groups to have negative phase, just as in a DEPT-135 spectrum. Figure 2 shows the multiplicity-edited HSQC (“HSQC-ME”) spectrum of our 400 mM quinine sample. The CH2 signals are shown in blue and the CH and CH3 signals in red.

 

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Live Benchtop NMR monitoring of Corning Flow Reactors at Achema

June 11th, 2018, by

At the Achema conference this week in Frankfurt we have a joint booth with Corning Advanced Flow Reactors.  We are running a live Spinsolve Benchtop NMR reaction monitoring setup in combination with a Corning Advanced Flow Reactor.  If you are Achema, please come and visit us at our joint booth with Corning AFR Hall 9.2 / Booth A32 and see the powerful combination of Corning Flow Reactors and Magritek Benchtop NMR.

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14th International Conference on the Applications of Magnetic Resonance in Food Science- Rennes, France, September 17-21, 2018

August 16th, 2018, by

Magritek is delighted to announce its participation at the MRFood 2018, which is being held at The Congress Center, Le Couvent des Jacobins of Rennes on September 17 – 21, 2018. Please stop at our booth and talk to our scientists about the capabilities and applications of the  Spinsolve Benchtop NMR system. Our applications and support team will have a live, working Spinsolve Benchtop NMR.

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Harrisburg University Uses the Spinsolve 60 MHz System as Part of Their Undergraduate Teaching Program

June 27th, 2018, by

Dr Catherine Santai is an Associate Professor of Chemistry & Biochemistry and Program Lead of the Integrative Sciences program at Harrisburg University of Science & Technology. The program utilizes a number of analytical techniques teaching undergraduates about their use, giving them the experience ahead of entering research or industrial roles in later life. So far, the Magritek 60 MHz Spinsolve Benchtop NMR Spectrometer has been used in the Organic Chemistry and Biochemistry laboratory sessions. These provide invaluable hands-on lessons about NMR techniques and analysis of a variety of compounds. NMR is used alongside FTIR (Fourier transfer infrared), AAS (atomic absorption), UV-VIS (ultraviolet – visible) and fluorescence spectroscopies.

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The APT Experiment

June 7th, 2018, by

The Attached Proton Test (APT) is a very useful experiment that, like DEPT, provides information about how many hydrogens or protons are attached to a particular carbon atom. Both DEPT and APT do this by “editing” the spectrum so that the carbon signals point either up or down depending on the number of attached hydrogens. APT differs from DEPT in several significant ways, though. The first is that quaternary carbons (i.e. carbons that bear no hydrogens) are retained in the APT spectrum, whereas they are absent in DEPT (though there are variants of the traditional DEPT experiment that do retain the quaternary signals). In APT, quaternary and methylene carbons point down by convention, while methyl and methine carbons point up. Figure 1 shows a comparison of a conventional carbon, APT and DEPT-135 spectra of a sample of propyl benzoate.

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