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KIT – Institut für Technische Chemie und Polymerchemie Karlsruher Institut für Technologie – Workshop Benchtop – NMR-Spektroskopie – Karlsruhe – Germany 23rd May 2017

April 10th, 2017, by

Magritek is really excited to be present at the Institute for Chemical
Technology and Polymer Chemistry at KIT, Karlsruhe, Germany for a workshop
on benchtop NMR spectroscopy on 23rd May 2017. We look forward to meeting
you. Our applications and support team will have a live, working Spinsolve
Benchtop NMR and will also be there to answer your benchtop NMR spectroscopy
questions.

The workshop will be held at Institut für Technische Chemie und Polymerchemie Karlsruher Institut für Technologie on the Engesserstr. 18, 76131 Karlsruhe.

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Jahrestreffen Reaktionstechnik 2017, Würzburg, Germany, 22nd – 24th May, 2017

December 6th, 2016, by

Magritek is really excited to be at Jahrestreffen Reaktionstechnik 2017 in Würzburg, Germany from 22nd – 24th May 2017. You can find us at Booth 5 and we really look forward to meeting you.Our team will have a live, working Spinsolve Benchtop NMR and our fabulous applications and support team will be there to answer all your benchtop NMR spectroscopy questions.

The Conference will take place on May 22nd & 24th, 2017,Tagungszentrum der Festung Marienberg in Würzburg.

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The Constant-Time COSY Experiment

August 7th, 2016, by

Despite the proliferation of new 2D techniques over the past four decades, one of the most commonly used experiments is the very first one to have come into existence, COSY1. It’s easy to see why it’s withstood the test of time: firstly, it’s an extremely useful experiment, providing a direct and easy way of establishing “through bond” proton-proton connectivities (“this hydrogen is near or next to that hydrogen”); secondly, because it’s a homonuclear 2D experiment (that is to say, it correlates protons with protons) its’s a very sensitive one. The high sensitivity also means that it’s a quick experiment to run, particularly if the experiment uses gradients for coherence selection (more on that below and in a future blog post).

Example COSY spectra recorded on Spinsolve can be found elsewhere on the Magritek website, but a typical example is also shown in Figure 1 below, recorded on a sample of ethyl crotonate. The sequence used to collect this spectrum utilizes gradients, meaning that it was run using only a single scan per t1 increment, and with 512 increments it only took 15 minutes to run.

Conventional COSY of ethyl crotonate

Fig. 1. COSY spectrum of ethyl crotonate, collected using gradients and 512 t1 increments.

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The NEW Spinsolve ULTRA – best resolution and lineshape

March 28th, 2017, by

Thrilled to announce the launch of the NEW Spinsolve ULTRA Benchtop NMR system. The Spinsolve ULTRA has the field homogeneity of a superconducting NMR magnet (0.2 Hz / 6 Hz / 12 Hz) in a compact and robust benchtop unit.

The Spinsolve ULTRA brochure can be downloaded here.

When combined with solvent suppression it allows users to resolve compounds dissolved at sub-millimolar concentrations in protonated solvents, such as water. The example below shows how effective the suppression of the very large water signal is. This enables metabolites at concentrations down to a few hundred micromolars to be detected in an 8 minute measurement.

Please contact us to discuss if Spinsolve ULTRA is useful for your application.

 

Updated examples of Spinsolve NMR spectra

March 6th, 2017, by

Our development team is constantly working on improving performance of the Spinsolve. And as a result the quality of NMR spectra you can obtain with Spinsolve has continued to improve. To show this, we have been updating the NMR spectral examples that are available on this website, and also updating Spinsolve 60 MHz data. So please go to Example NMR Spectra and browse through the page. Hope you find these examples useful!

The Chemistry Department of the University of Helsinki uses a Magritek Spinsolve Benchtop NMR spectrometer

December 14th, 2016, by

Dr Leena Kaisalo heads up the Organic Chemistry student laboratory at the University of Helsinki. While the Laboratory’s research focuses on organic synthesis, Dr Kaisalo’s role is to lead the teaching of bachelor and masters students in various analytical techniques including NMR.

magritek-helsinki-nmr

Dr Leena Kaisalo uses her Magritek Spinsolve Benchtop NMR Spectrometer at the University of Helsinki Chemistry Department

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Karel de Grote University College in Antwerp uses Spinsolve for research and teaching

November 1st, 2016, by

Dr Jeroen Geuens is a member of the Centre of Expertise on Sustainable Chemistry (CESC) based in Antwerp at the Karel de Grote University College. The Centre specialises in research and services related to chemical and production processes together with offering professional degree courses.

Before discovering the Spinsolve benchtop NMR from Magritek they could only get access to NMR measurements by taking their samples to the University of Antwerp. The Spinsolve is now used continuously for both teaching and research in the CESC. Dr Geuens takes up the story.

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Benchtop qNMR evaluation

September 18th, 2016, by

In an earlier post on qNMR we described how benchtop NMR can be used to quantify the concentration of a sample or measure its purity. When such quantitative methods are validated, there are standard requirements for accuracy, precision, range, and linearity over that range that need to be met.

For example, the United States Pharmacopeia (USP) specifies the general requirements for a Category I NMR method when measuring a drug substance (there are other specifications for finished products and impurities). These specifications are listed in the table at the end of this post and are compared to the measured Spinsolve performance.

We have validated the Spinsolve benchtop qNMR performance by measuring the purity of one reference standard, methylsulfonylmethane (MSM), with another, maleic acid. Maleic acid is a common reference standard for qNMR, so this was used as the reference to measure the known purity of MSM (specified 99.5% pure). A spectrum of the mixture in D2O is shown in Figure 1.

Spectrum of MSM and maleic acid in D2O

Figure 1: Spectrum of MSM and maleic acid in D2O.

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New Spinsolve Publications

March 19th, 2017, by

The Spinsolve is not only a perfect tool to teach NMR to Chemistry students, but its performance enables it to be used for serious research. This is evidenced in the published papers from our users. Over the last few months there has been a number of new publications featuring Spinsolve. In this post we will highlight a few of them. Click here for a full comprehensive list of publications.

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20th European Symposium on Organic Chemistry 2017, Cologne – Germany, 2nd – 6th July 2017

January 19th, 2017, by

Magritek is really excited to be at 20th European Symposium on Organic Chemistry 2017 in Cologne, Germany from 2nd – 6th July 2017.  You can find us at Booth 12 and we really look forward to meeting you. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.

ESOC

esoc-uni

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Euromar 2017, Warsaw – Poland, 2nd – 6th July 2017

December 6th, 2016, by

Magritek is really excited to be at EUROMAR 2017 in Warsaw, Poland from 2nd – 6th July 2017.  You can find us at Booth 1B and we really look forward to meeting you. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.

euromar_2017

The venue will be the prestigious Warsaw Marriott Al. Jerozolimskie 65/79  Warsaw  00-697  Poland . (more…)

Stream the Webinar: Thinking Outside the (Benchtop) Box – High-Field NMR Techniques on Benchtop Instruments

October 29th, 2016, by

Did you miss our recent webinar ? No problem, just click the red button below to stream a replay of the webinar held on 27th October 2016: Thinking Outside the (Benchtop) Box – High-Field NMR Techniques on Benchtop Instruments

 




Stream the Webinar Recording



 

In this webinar you will learn about:

  • High-field techniques that are now possible on benchtop instruments.
  • Applications and problems solved by advancements in benchtop NMR spectroscopy.
  • The size, ease-of-use, and economic advantages of benchtop instruments over high-field machines.

In recent years benchtop NMR spectrometers have become an increasingly viable alternative to high-field systems. Many demanding resolution and sensitivity requirements can now be met with modern methods and instruments. In this webinar we illustrate how a number of well-established and modern high-field NMR techniques, such as 2D, non-uniform sampling (NUS), and pure shift experiments, can be implemented on a benchtop NMR system to solve problems and applications previously considered beyond reach.

Quantitative benchtop NMR

September 12th, 2016, by

Quantification using any analytical method requires calibrating an instrumental response with a known reference, and then calculating the concentration of an unknown sample from the measured instrument response. One advantage of NMR compared to other analytical methods is that the signal response is linear, resulting the NMR signal intensity being proportional to the number of nuclei.

Sample concentrations and purities can be easily measured from known peaks once the proportionality constant is calibrated using a reference of known concentration and purity. Such measurement methods are known as quantitative NMR, or qNMR for short.

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