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Annual Meeting of the German Pharmaceutical Society – DPhG in Saarbrücken on 26th to 29th September 2017

September 8th, 2017, by

Magritek is really excited to be present at the Annual Meeting of the German Pharmaceutical Society – DPhG in Saarbrücken on 26th to 29th September 2017.We really look forward to meeting you at Magritek booth. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.

The Congress will take place at Saarland University, Campus E2.2 and E2.5, 66123 Saarbrücken.

University College Leuven Limburg use Spinsolve in their undergraduate organic chemistry laboratory program

August 23rd, 2017, by

Dr Hilde Roex is the co-ordinator of the second year organic chemistry laboratory course of the Chemistry Program (Gasthuisberg campus, Faculty Management & Technology). Here, the students apply NMR in their organic chemistry laboratory to identify the molecular structure of their synthesized products. They are taught to see the value of NMR for quality control and its use alongside other analytical methods including gas and liquid chromatography. Their goal is to be able to interpret proton NMR spectra and to learn that proton NMR and FT-IR spectroscopy are complementary techniques. This helps to make students familiar with NMR showing them applications of its wide use in industry.

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SMASH 2017- Baveno – Italy 17th – 20th September 2017

July 9th, 2017, by

Magritek is really excited to be present at SMASH 2017 in Baveno, Italy from 17th – 20th September 2017 .We really look forward to meeting you. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.

The Small Molecule NMR Conference will take place at the Grand Hotel Dino in Baveno – Corso Giuseppe Garibaldi, 20, 28831 Baveno VB, Italy.

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Ley Group at Cambridge uses Spinsolve Benchtop NMR as part of their flow chemistry and organic synthesis research

June 22nd, 2017, by

Professor Steven Ley’s laboratories are located in the Department of Chemistry at the University of Cambridge. Their research specialises in flow chemistry and organic synthesis. They are renowned for collaborations with academic and industrial partners. Précising their work, Steve says

“Complex synthesis remains a challenging occupation requiring an exceptional level of experimental skill, extensive knowledge of both mechanistic and molecular reactivity, and a bold, inventive, and creative spirit. It is the combination of these qualities that transforms the synthesis process from one of simple logistics to an art form.”

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Compact NMR symposium 18-19 October 2017

June 9th, 2017, by

There is two-day symposium devoted to recent developments and applications on benchtop NMR is being held in Nantes, France, on 18-19 October 2017. Registration is free but mandatory and can be done here
http://www.sciences.univ-nantes.fr/CEISAM/web/compact_NMR_symposium/

The invited speakers are

80 MHz Benchtop NMR – Introducing Spinsolve 80

May 30th, 2017, by

We are really excited to introduce the newest Spinsolve benchtop NMR – the 80MHz Spinsolve 80. Spinsolve 80 combines industry leading resolution (0.5 Hz/20 Hz) and the highest sensitivity and chemical shift dispersion with an unparalleled 80 MHz magnet at its core. All Spinsolve benchtop NMR systems include easy to use software, convenient size and weight, and superior stability to give you quick and convenient NMR spectroscopy, wherever you want it.

To download a brochure and learn more please click on the image below

Download the brochure.

If you have any other questions about Spinsolve 80, or any of our products, please contact us.

 

 

Silicon NMR on Spinsolve – Part 2

August 30th, 2017, by

In my last blog post I introduced silicon NMR on Spinsolve and showed a variety of 1D 29Si{1H} and 29Si-1H DEPT spectra. In this post I’m moving on to talk about some 2D experiments that are useful for silicon studies. One of the most useful and widely used of those is the 1H-29Si HMBC experiment, which correlates proton and silicon chemical shifts over two or more chemical bonds. For example, Figure 1 below shows a 1H-29Si HMBC spectrum of the 1,1,3,3,5,5-hexamethyltrisiloxane sample I used before, collected in around 17 minutes. The 1H spectrum is shown along the horizontal axis of the 2D spectrum, and the 29Si spectrum is shown along the vertical axis.

Fig. 1. 1H-29Si HMBC spectrum of 1,1,3,3,5,5-hexamethyltrisiloxane

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39th Diskussionstagung der Fachgruppe NMR – Bayreuth, Germany 25th – 28th September 2017.

August 11th, 2017, by

Magritek is really excited to be present at 39th Diskussionstagung der Fachgruppe NMR from GDCh in Bayreuth, Germany from 25th – 28th September 2017.We really look forward to meeting you. Our applications and support team will have a live, working Spinsolve Benchtop NMR and will also be there to answer all your benchtop NMR spectroscopy questions.

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Silicon NMR on Spinsolve – Part 1

June 22nd, 2017, by

Silicon is one of the most widespread elements in the natural world and, as such, this makes it a very interesting and useful element to study using NMR. Over the past few decades, a wide range of silicon-containing compounds have been investigated using both solid- and liquid-state NMR techniques. For example, siloxane polymers, which are extensively used in biomedical and cosmetic applications, have been extensively studied by NMR to understand their structure and individual building blocks. Similarly, the structure of silicates, zeolites and other materials have been studied by silicon NMR. Silicon NMR has been shown to be a powerful tool for the determination of active end groups, cross-linking moieties and polymer sequencing.

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RIVM in the Netherlands uses the Spinsolve benchtop NMR spectrometer to investigate illegal drugs

June 8th, 2017, by

Dr Peter Keizers is a scientist in the Centre for Health Protection at RIVM, the Dutch National Institute for Public Health and the Environment based in Bilthoven. As a chemist, he investigates (illegal) drugs, medical devices and other medicinal products. His group studies the composition of these products and specifically look for active pharmaceutical ingredients, preferably in a quantitative way.


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Magritek and Quantum Design announce distribution partnership for Spinsolve in South America

August 30th, 2017, by

San Diego 10th August 2017: Magritek, a leading provider of compact NMR and MRI instruments, and Quantum Design, a leading manufacturer and distributor of scientific and industrial instrumentation announce their new distribution partnership. Under the new agreement, Quantum Design South America will distribute Magritek’s product line of Spinsolve Benchtop NMR Spectrometers in South America.

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Chemistry Department at Lyon College, Arkansas, uses Spinsolve for research and teaching

July 26th, 2017, by

Dr Irosha Nawarathne is an Assistant Professor in the Chemistry Department at Lyon College, a selective liberal arts institution in rural Arkansas. Her work bridges biomedical research to teaching students the practical use of instrumentation to prepare them for employment and the challenges of the chemical industry. She summarizes her experience with the Spinsolve, which was added to the Chemistry Department in 2015:

Spinsolve has become the most popular among faculty and students of our chemistry program. It is used in organic chemistry, instrumental analysis, and advanced inorganic chemistry laboratories. We plan to extend the usage to other areas too. Students have become very interested in the concept of NMR because of this instrument. Their knowledge of NMR is improved tremendously after the incorporation of Spinsolve in the chemistry program. It is easy to operate, provides quick analysis, and requires very low maintenance. Spinsolve is definitely the best fit for a small college like ours. We formerly had a cryogenic NMR spectrometer at Lyon but the chemistry program has not been able to maintain the instrument in the long term. Spinsolve is low cost and its low maintenance is key for its great fit to Lyon chemistry program. It is also used in recruiting keen students as they get really excited about the instrument and its capabilities during frequent campus tours.

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13C NMR of Cholesterol on an 80 MHz magnet

June 14th, 2017, by

Cholesterol is an essential molecule found in all animals and is a structural component of animal cell membranes. It is the reason why animal cells are flexible and animals can move, unlike plant cells which have rigid cell walls. Cholesterol is a sterol and the cells in your body synthesize about 1 gram every day.

With recent advances in the performance of benchtop NMR, such as the 80 MHz Spinsolve 80, it is interesting to see the 13C NMR spectra from molecules such as Cholesterol.  With a molecular weight of 386 g/mol and 27 carbon atoms it is a larger molecule than is typical measured on a Carbon-13 capable benchtop NMR spectrometer. Because there are more peaks to resolve, both the sensitivity and resolution of the instrument are tested with this measurement.

The 1D proton-decoupled 13C NMR spectrum of a 400 mM sample of Cholesterol measured by a Spinsolve 80 is shown in the figure below. Because 13C has a lower gyromagnetic ratio than protons, the 13C Larmor frequency is 20 MHz. The region between 20 ppm and 45 ppm has been expanded to show how the carbon peaks are resolved.

Spinsolve 80: Quinine HSQC-ME example

May 30th, 2017, by

One of the advanced features of the Spinsolve 80 is the ability to run a Multiplicity Edited HSQC, also known as HSQC-ME.  This powerful 2D NMR sequence has proton in the horizontal (f2) axis and carbon in the vertical (f1) axis.  The peaks appear where a proton is connected to a carbon atom.  Additional information about “multiplicity” is given by the sign of the peak, just like in a DEPT experiment.  Positive peaks (red) are either CH or CH3, while negative peaks (blue) are from CH2. This additional information really helps with correct peak assignment.

The example below is from an HSQC-ME experiment run on a sample of Quinine and shows all the peaks uniquely resolved and assigned.