HTBLA Wels is a higher technical vocational college of chemistry in Austria. Here, Dr Harald Baumgartner is responsible for the instrumental analytical laboratory. The lab’s main focus is to teach students the basics of NMR (interpretation of spectra).
Dr Baumgartner says “Compared to the old 60 MHz spectrometer, the Magritek Spinsolve benchtop spectrometer is so much easier to use. It is software-based so collecting and processing data is quite straightforward. As well as 1H spectra, our Spinsolve allows us to measure more complex spectra including 13C-spectra. Even 2-dimensional experiments are now available to the students.”
A college student learns about NMR with the Magritek Spinsolve Carbon at HTLBA Wels in Austria
Dr Jonathan Harburn is a Lecturer in Medicinal Chemistry in the Wolfson Research Institute located in the School of Medicine, Pharmacy and Health at Durham University. Working together with Drs Stuart Cockerill and Jonathan Sellars, Dr Harburn’s research goals are to create clinical drug candidates for the treatment of viruses, bacteria and cancer.
In their research, recent progress has focussed repurposing novel fluorinated drug fragments on known drug scaffolds to develop hit identification. 19F NMR using Spinsolve is one of the most useful tools in confirming fluorinated fragment incorporation with spectra run in 3 minutes. Also, 1H NMR is routinely carried out for identification before further spectral data is acquired on higher field NMR.
Alistair Paterson, a Level 2 MPharm student at Durham University, uses Spinsolve to evaluate his sulfathiazole sample
Dr Alan Kenwright is Reader in Spectroscopy and Manager of the solution-state NMR facility in the Chemistry Department at Durham University. His personal research is focussed on developing and using NMR techniques to solve a range of chemical problems. In choosing to use Magritek’s Spinsolve, Dr Kenwright anticipates it will allow the extension of his work in various areas in ways that he could not otherwise. He plans to use the equipment initially in three areas:
Dr Nicola Rogers is a post doc in the Kenwright group using the Magritek Spinsolve to make relaxation measurements on lanthanide complexes at Durham University. For ease of use, it is mounted on a trolley making it easy to move from lab to lab.
“The first application is in looking at lanthanide complexes of the sort used as contrast agents for MRI” … “being able to do measurements in the relatively low magnetic field (43 MHz) used by Magritek’s Spinsolve is a big advantage for us, particularly as the field it uses it not very different to the field actually used in many hospital MRI scanners. These measurements using the Spinsolve are just starting to appear in the literature.” (reference given at the end of this blog post)
Cleveland State University in Ohio is developing into one of the best urban universities in the nation. Investment at the ground roots graduate level is illustrated by the recent purchase of benchtop NMR spectrometry to offer students hands-on experience of the latest in scientific instrumentation.
Dr Vania De Paoli is an associate college lecturer in the Department of Chemistry where she is leading a program to create a solid environment for teaching Organic Chemistry. Prior to investing in the Magritek benchtop NMR spectrometer, students‘ practical options were limited to the measurement of melting points and refractive index. Students were not experiencing anything close to life in a modern organic chemistry laboratory.
As Dr De Paoli says, the Spinsolve has changed this position immensely. “It is a small system, portable and lightweight. It is quickly ready to use allowing the students to have a real NMR analysis experience (they prepare the samples in standard NMR tubes, add the solvent and record the spectra in similar ways to a research grade NMR). The spectra are of good quality. The software is friendly and, overall, Spinsolve is readily affordable.”
At the recent American Chemical Society meeting held in in San Diego in March, we launched our exciting new 60 MHz line of Spinsolve benchtop NMR spectrometers. Click the image below to watch the short video that we made at ACS during the launch.
Dr Maria Vogt is Professor of Chemistry at Bloomfield College in New Jersey where she teaches lectures and runs labs in Organic Chemistry and Biochemistry. Having had a prior research career and publishing more than 45 papers, Dr Vogt now devotes her efforts to prepare students for the “real world” by exposing them to as many hands-on and instrumental skills as possible prior to graduation. She encourages the development of problem-solving skills. NMR spectra are used as “puzzles” through which the students are pushed to use their brain to figure out unknown samples in their practical classes.
Dr Vogt is enthusiastic about introducing practical hands-on NMR to her students “Analyzing an NMR spectrum is just plain fun! NMR is essential at many levels of chemistry. It is essential in graduate school and industries such as foods and pharmaceuticals. Providing a foundation in the analysis of simple samples by NMR at the undergraduate level will help prepare my students for the interpretation of the much more complex spectra of more complex molecules.”
Undergraduate chemistry major, Tytianna Drew, uses the Magritek Spinsolve benchtop NMR spectrometer in her organic chemistry classes. Her college laboratory experience has earned her a summer internship at global biopharmaceutical company, Celgene Corporation, headquartered in New Jersey.(more…)
In NMR spectroscopy it is useful when the raw data files from the instrument are saved such that they can open in data analysis software from another vendor. For example, by saving Spinsolve data files in JCAMP-DX you can open and process the data in a range of software including Mestrelab MNova, ACD/Spectrus, and Bruker’s TopSpin.
Magritek have taken this integration one step further and you can now directly operate the Spinsolve benchtop NMR spectrometer using a special version of the Bruker IconNMR control and acquisition software. It is then a single step to directly open the data in TopSpin for detailed analysis.
Students can now gain valuable hands-on experience running IconNMR and TopSpin on a compact robust cost-effective NMR spectrometer. This gives students the experience of using the same software interface they might use later in their course on a higher field NMR spectrometer. This reduces the learning curve and barriers to using NMR. (more…)
At today’s opening of the 2016 Spring ACS conference in San Diego California, Magritek are pleased to launch their newest series of benchtop NMR spectrometers, the Spinsolve 60. Operating at 62 MHz, the increased dispersion and sensitivity of the Spinsolve 60 spectrometer offers added measurement capability that is desired for many demanding applications.
The Spinsolve 60 spectrometer has the identical compact form factor of Magritek’s already successful Spinsolve series spectrometers, enabling it to fit conveniently on the chemistry bench, or on a small trolley. The Spinsolve 60 spectrometer is initially available with proton/fluorine or proton/fluorine/carbon. Other nuclei will be added in the near future.