Blog posts by Bertram

Wageningen University & Research uses the Spinsolve 60 MHz System as Part of Their Undergraduate Teaching Program

February 21st, 2018, by

Wageningen University & Research (WUR) is formed from the collaboration between Wageningen University and the Wageningen Research foundation. With the mission “to explore the potential of nature to improve the quality of life,” its staff and students work in the domain of healthy foods and living environments. Dr Teris van Beek is a Lecturer in the Department of Agrotechnology & Food Sciences. Among his responsibilities is the coordination of the undergraduate course in analytical chemistry where 220 molecular life sciences and biotechnology students are introduced to practical spectroscopy each year (UV, IR, MS, NMR, structure elucidation).


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Spinsolve as an optimisation tool for a catalyst-free flow reaction

February 15th, 2018, by

The group of Professor Yoshida at the Department of Synthetic Chemistry and Biological Chemistry of Kyoto University has recently published an article showing how Spinsolve benchtop NMR spectroscopy can be used to optimise the reactions of aminating reagents to achieve an efficient C–N bond formation without using any catalyst.


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New Publications on Real-Time Reaction Monitoring

December 14th, 2017, by

Two recent publications (link here and here) in international journals highlight the potential of using the Spinsolve benchtop NMR for real time chemical reaction monitoring.  Interest in using NMR spectroscopy to monitor chemical reactions has been increasing as the information can be used to optimise yield and minimise waste in order to enhance sustainability of the production process.

One of papers from the Ley group at Cambridge University (Musio et al., ACS Sustainable Chem. Eng, 2017) describes how real-time reaction monitoring on Fluorine can be used to optimise the reaction and reduce the environmental impact in the synthesis of functional fluorinated products. The other paper from the Blümich group at RWTH Aachen (Singh et al., Anal. Bioanal. Chem., 409, pp 7223–7234, 2017) evaluates the on-line benchtop NMR reaction monitoring method against off-line GC and high-field NMR methods and finds excellent agreement between them.

New Publications Featuring Spinsolve in Education

October 4th, 2017, by

Two nice educational applications of Spinsolve benchtop NMR have been published recently as open access in international journals. These papers can be downloaded for free from the links given below. The first one describes a simple method to measure the octanol-water partition coefficient of an organic compound. The second one demonstrates a method to determine the pKa value of some biologically active pyridine-based drugs.

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University College Leuven Limburg use Spinsolve in their undergraduate organic chemistry laboratory program

August 23rd, 2017, by

Dr Hilde Roex is the co-ordinator of the second year organic chemistry laboratory course of the Chemistry Program (Gasthuisberg campus, Faculty Management & Technology). Here, the students apply NMR in their organic chemistry laboratory to identify the molecular structure of their synthesized products. They are taught to see the value of NMR for quality control and its use alongside other analytical methods including gas and liquid chromatography. Their goal is to be able to interpret proton NMR spectra and to learn that proton NMR and FT-IR spectroscopy are complementary techniques. This helps to make students familiar with NMR showing them applications of its wide use in industry.

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Chemistry Department at Lyon College, Arkansas, uses Spinsolve for research and teaching

July 26th, 2017, by

Dr Irosha Nawarathne is an Assistant Professor in the Chemistry Department at Lyon College, a selective liberal arts institution in rural Arkansas. Her work bridges biomedical research to teaching students the practical use of instrumentation to prepare them for employment and the challenges of the chemical industry. She summarizes her experience with the Spinsolve, which was added to the Chemistry Department in 2015:

Spinsolve has become the most popular among faculty and students of our chemistry program. It is used in organic chemistry, instrumental analysis, and advanced inorganic chemistry laboratories. We plan to extend the usage to other areas too. Students have become very interested in the concept of NMR because of this instrument. Their knowledge of NMR is improved tremendously after the incorporation of Spinsolve in the chemistry program. It is easy to operate, provides quick analysis, and requires very low maintenance. Spinsolve is definitely the best fit for a small college like ours. We formerly had a cryogenic NMR spectrometer at Lyon but the chemistry program has not been able to maintain the instrument in the long term. Spinsolve is low cost and its low maintenance is key for its great fit to Lyon chemistry program. It is also used in recruiting keen students as they get really excited about the instrument and its capabilities during frequent campus tours.

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Ley Group at Cambridge uses Spinsolve Benchtop NMR as part of their flow chemistry and organic synthesis research

June 22nd, 2017, by

Professor Steven Ley’s laboratories are located in the Department of Chemistry at the University of Cambridge. Their research specialises in flow chemistry and organic synthesis. They are renowned for collaborations with academic and industrial partners. Précising their work, Steve says

“Complex synthesis remains a challenging occupation requiring an exceptional level of experimental skill, extensive knowledge of both mechanistic and molecular reactivity, and a bold, inventive, and creative spirit. It is the combination of these qualities that transforms the synthesis process from one of simple logistics to an art form.”

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About Bertram

Bertram works as Senior Applications Engineer for Magritek in Wellington. He gained his PhD under the supervision of Paul Callaghan and has been working in the field of NMR technology for over 20 years.