Blog posts by andrew

Characterizing Fatty Acids with advanced multinuclear NMR methods

April 6th, 2018, by

Download the full application note by clicking here (PDF)

Fatty acids consist of long carbon chains ending with a carboxylic acid on one side and a methyl group on the other. Most naturally occurring fatty acids have an even number of carbon atoms and can be either saturated or unsaturated. Unsaturated fatty acids have one or more double bonds between carbon atoms. Typical fatty acids found in vegetable oils are saturated palmitic acid (C16:0) and stearic acid (C18:0), as well as oleic acid (C18:1) with a single double bond starting at carbon nine (omega-9), linoleic acid (C18:2) with two double bonds starting at position 6 (omega-6), and alpha-linolenic acid with three double bonds starting at position 3 (omega-3).
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Thought Leader Interview: Prof Patrick Giraudeau

February 19th, 2018, by

A fascinating thought leader interview with Prof Patrick Giraudeau from the University of Nantes discusses how his group uses their Spinsolve benchtop NMR spectrometer for applications such as reaction monitoring, edible oil analysis and implementing ultrafast 2D NMR.

Benchtop NMR systems are better suited to reaction monitoring than high-field systems

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NMR spectroscopy outdoors at a natural gas plant

February 7th, 2018, by

Professor Mike Johns at the University of Western Australia shared this story about doing NMR outdoors with one of their Spinsolve spectrometers. The outdoor environment presents a number of challenges for any analytical instrument and not normally a place you would find NMR spectrometers. Great to hear the trial was successful. Details and pictures below.

In collaboration with Chevron and Woodside, the Fluid Science and Resources Research Group at the University of Western Australia (UWA) trialled a ppm oil-in water measurement protocol built around solid phase extraction and a Magritek 1H 43 MHz Spinsolve benchtop NMR spectrometer. This occurred in October 2017 on the Woodside Pluto LNG plant in North West Australia. Measurements were performed outside, adjacent to the waste water treatment plant, using the SPE-NMR apparatus shown below. The trial was successful with measurements being consistent with laboratory data over a two week period.

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13C NMR of Cholesterol on an 80 MHz magnet

June 14th, 2017, by

Cholesterol is an essential molecule found in all animals and is a structural component of animal cell membranes. It is the reason why animal cells are flexible and animals can move, unlike plant cells which have rigid cell walls. Cholesterol is a sterol and the cells in your body synthesize about 1 gram every day.

With recent advances in the performance of benchtop NMR, such as the 80 MHz Spinsolve 80, it is interesting to see the 13C NMR spectra from molecules such as Cholesterol.  With a molecular weight of 386 g/mol and 27 carbon atoms it is a larger molecule than is typical measured on a Carbon-13 capable benchtop NMR spectrometer. Because there are more peaks to resolve, both the sensitivity and resolution of the instrument are tested with this measurement.

The 1D proton-decoupled 13C NMR spectrum of a 400 mM sample of Cholesterol measured by a Spinsolve 80 is shown in the figure below. Because 13C has a lower gyromagnetic ratio than protons, the 13C Larmor frequency is 20 MHz. The region between 20 ppm and 45 ppm has been expanded to show how the carbon peaks are resolved.

Spinsolve 80: Quinine HSQC-ME example

May 30th, 2017, by

One of the advanced features of the Spinsolve 80 is the ability to run a Multiplicity Edited HSQC, also known as HSQC-ME.  This powerful 2D NMR sequence has proton in the horizontal (f2) axis and carbon in the vertical (f1) axis.  The peaks appear where a proton is connected to a carbon atom.  Additional information about “multiplicity” is given by the sign of the peak, just like in a DEPT experiment.  Positive peaks (red) are either CH or CH3, while negative peaks (blue) are from CH2. This additional information really helps with correct peak assignment.

The example below is from an HSQC-ME experiment run on a sample of Quinine and shows all the peaks uniquely resolved and assigned.

80 MHz Benchtop NMR – Introducing Spinsolve 80

May 30th, 2017, by

We are really excited to introduce the newest Spinsolve benchtop NMR – the 80MHz Spinsolve 80. Spinsolve 80 combines industry leading resolution (0.5 Hz/20 Hz) and the highest sensitivity and chemical shift dispersion with an unparalleled 80 MHz magnet at its core. All Spinsolve benchtop NMR systems include easy to use software, convenient size and weight, and superior stability to give you quick and convenient NMR spectroscopy, wherever you want it.

To download a brochure and learn more please click on the image below

Download the brochure.

If you have any other questions about Spinsolve 80, or any of our products, please contact us.

 

 

The NEW Spinsolve ULTRA – best resolution and lineshape

March 28th, 2017, by

Thrilled to announce the launch of the NEW Spinsolve ULTRA Benchtop NMR system. The Spinsolve ULTRA has the field homogeneity of a superconducting NMR magnet (0.2 Hz / 6 Hz / 12 Hz) in a compact and robust benchtop unit.

The Spinsolve ULTRA brochure can be downloaded here.

When combined with solvent suppression it allows users to resolve compounds dissolved at sub-millimolar concentrations in protonated solvents, such as water. The example below shows how effective the suppression of the very large water signal is. This enables metabolites at concentrations down to a few hundred micromolars to be detected in an 8 minute measurement.

Please contact us to discuss if Spinsolve ULTRA is useful for your application.

 

The Chemistry Department of the University of Helsinki uses a Magritek Spinsolve Benchtop NMR spectrometer

December 14th, 2016, by

Dr Leena Kaisalo heads up the Organic Chemistry student laboratory at the University of Helsinki. While the Laboratory’s research focuses on organic synthesis, Dr Kaisalo’s role is to lead the teaching of bachelor and masters students in various analytical techniques including NMR.

magritek-helsinki-nmr

Dr Leena Kaisalo uses her Magritek Spinsolve Benchtop NMR Spectrometer at the University of Helsinki Chemistry Department

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Karel de Grote University College in Antwerp uses Spinsolve for research and teaching

November 1st, 2016, by

Dr Jeroen Geuens is a member of the Centre of Expertise on Sustainable Chemistry (CESC) based in Antwerp at the Karel de Grote University College. The Centre specialises in research and services related to chemical and production processes together with offering professional degree courses.

Before discovering the Spinsolve benchtop NMR from Magritek they could only get access to NMR measurements by taking their samples to the University of Antwerp. The Spinsolve is now used continuously for both teaching and research in the CESC. Dr Geuens takes up the story.

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Stream the Webinar: Uncover the Potential of Benchtop NMR in Forensics Labs

July 13th, 2016, by

Click the red button below to stream a replay of our webinar held on 12th July 2016: Uncover the potential of Benchtop NMR in Forensics Labs


Stream the forensics webinar



In this webinar you will learn about:

  • Analytical properties of benchtop NMR uniquely suited to drug identification and quantification.
  • How to distinguish related compounds, including isomers, using benchtop NMR.
  • The potential for benchtop NMR to become a standard technique in forensics laboratories.

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About andrew

Andrew is the CEO of Magritek and has led the company from its foundation as a University spin out company to its current position as a fast-growing, profitable exporter. He brings both commercial and technical experience to the company having worked in senior management roles for companies in Sydney and London. Andrew has a PhD in Physics from Massey University, is a 2011 Sir Peter Blake Emerging Leader and was a member of the team that won the 2010 Prime Minister’s Science Prize.