Blog posts by andrew

13C NMR of Cholesterol on an 80 MHz magnet

June 14th, 2017, by

Cholesterol is an essential molecule found in all animals and is a structural component of animal cell membranes. It is the reason why animal cells are flexible and animals can move, unlike plant cells which have rigid cell walls. Cholesterol is a sterol and the cells in your body synthesize about 1 gram every day.

With recent advances in the performance of benchtop NMR, such as the 80 MHz Spinsolve 80, it is interesting to see the 13C NMR spectra from molecules such as Cholesterol.  With a molecular weight of 386 g/mol and 27 carbon atoms it is a larger molecule than is typical measured on a Carbon-13 capable benchtop NMR spectrometer. Because there are more peaks to resolve, both the sensitivity and resolution of the instrument are tested with this measurement.

The 1D proton-decoupled 13C NMR spectrum of a 400 mM sample of Cholesterol measured by a Spinsolve 80 is shown in the figure below. Because 13C has a lower gyromagnetic ratio than protons, the 13C Larmor frequency is 20 MHz. The region between 20 ppm and 45 ppm has been expanded to show how the carbon peaks are resolved.

Spinsolve 80: Quinine HSQC-ME example

May 30th, 2017, by

One of the advanced features of the Spinsolve 80 is the ability to run a Multiplicity Edited HSQC, also known as HSQC-ME.  This powerful 2D NMR sequence has proton in the horizontal (f2) axis and carbon in the vertical (f1) axis.  The peaks appear where a proton is connected to a carbon atom.  Additional information about “multiplicity” is given by the sign of the peak, just like in a DEPT experiment.  Positive peaks (red) are either CH or CH3, while negative peaks (blue) are from CH2. This additional information really helps with correct peak assignment.

The example below is from an HSQC-ME experiment run on a sample of Quinine and shows all the peaks uniquely resolved and assigned.

80 MHz Benchtop NMR – Introducing Spinsolve 80

May 30th, 2017, by

We are really excited to introduce the newest Spinsolve benchtop NMR – the 80MHz Spinsolve 80. Spinsolve 80 combines industry leading resolution (0.5 Hz/20 Hz) and the highest sensitivity and chemical shift dispersion with an unparalleled 80 MHz magnet at its core. All Spinsolve benchtop NMR systems include easy to use software, convenient size and weight, and superior stability to give you quick and convenient NMR spectroscopy, wherever you want it.

To download a brochure and learn more please click on the image below

Download the brochure.

If you have any other questions about Spinsolve 80, or any of our products, please contact us.

 

 

The NEW Spinsolve ULTRA – best resolution and lineshape

March 28th, 2017, by

Thrilled to announce the launch of the NEW Spinsolve ULTRA Benchtop NMR system. The Spinsolve ULTRA has the field homogeneity of a superconducting NMR magnet (0.2 Hz / 6 Hz / 12 Hz) in a compact and robust benchtop unit.

The Spinsolve ULTRA brochure can be downloaded here.

When combined with solvent suppression it allows users to resolve compounds dissolved at sub-millimolar concentrations in protonated solvents, such as water. The example below shows how effective the suppression of the very large water signal is. This enables metabolites at concentrations down to a few hundred micromolars to be detected in an 8 minute measurement.

Please contact us to discuss if Spinsolve ULTRA is useful for your application.

 

The Chemistry Department of the University of Helsinki uses a Magritek Spinsolve Benchtop NMR spectrometer

December 14th, 2016, by

Dr Leena Kaisalo heads up the Organic Chemistry student laboratory at the University of Helsinki. While the Laboratory’s research focuses on organic synthesis, Dr Kaisalo’s role is to lead the teaching of bachelor and masters students in various analytical techniques including NMR.

magritek-helsinki-nmr

Dr Leena Kaisalo uses her Magritek Spinsolve Benchtop NMR Spectrometer at the University of Helsinki Chemistry Department

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Karel de Grote University College in Antwerp uses Spinsolve for research and teaching

November 1st, 2016, by

Dr Jeroen Geuens is a member of the Centre of Expertise on Sustainable Chemistry (CESC) based in Antwerp at the Karel de Grote University College. The Centre specialises in research and services related to chemical and production processes together with offering professional degree courses.

Before discovering the Spinsolve benchtop NMR from Magritek they could only get access to NMR measurements by taking their samples to the University of Antwerp. The Spinsolve is now used continuously for both teaching and research in the CESC. Dr Geuens takes up the story.

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Stream the Webinar: Uncover the Potential of Benchtop NMR in Forensics Labs

July 13th, 2016, by

Click the red button below to stream a replay of our webinar held on 12th July 2016: Uncover the potential of Benchtop NMR in Forensics Labs


Stream the forensics webinar



In this webinar you will learn about:

  • Analytical properties of benchtop NMR uniquely suited to drug identification and quantification.
  • How to distinguish related compounds, including isomers, using benchtop NMR.
  • The potential for benchtop NMR to become a standard technique in forensics laboratories.

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Learn about the latest Spinsolve developments at ENC

April 7th, 2016, by

Magritek CEO Dr Andrew Coy will be announcing the latest Spinsolve benchtop NMR features at ENC during the Mestelab Users Meeting on Sunday 10th April at 1.30pm.  The talk will show how modern high-field NMR experiments and techniques, such as Non-Uniform Sampling (NUS) and Pureshift protocols can be implemented and run on the Spinsolve benchtop NMR Spectrometer. Included in the presentation will be details on the new Spinsolve 60 launched at the ACS meeting in San Diego a few weeks ago.

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Benchtop NMR Workshop 15th March at ACS

March 1st, 2016, by

Join the Spinsolve Benchtop NMR Workshop being held Tuesday 15th March from 10am-noon at ACS Spring meeting. Please use the link below to register.




Register for the Workshop



  • Learn how chemistry students are applying Spinsolve benchtop NMR to everyday problems, in both the class room and research lab.
  • Discover the latest applications of Spinsolve NMR that are fundamentally changing how Industry is using NMR for QA/QC
  • Hear about the new Spinsolve benchtop NMR being launched at ACS.
  • See how benchtop NMR can be used for reaction monitoring and to determine reaction endpoints in real time

 

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About andrew

Andrew is the CEO of Magritek and has led the company from its foundation as a University spin out company to its current position as a fast-growing, profitable exporter. He brings both commercial and technical experience to the company having worked in senior management roles for companies in Sydney and London. Andrew has a PhD in Physics from Massey University, is a 2011 Sir Peter Blake Emerging Leader and was a member of the team that won the 2010 Prime Minister’s Science Prize.