Blog posts by andrew

Introducing the new Spinsolve Autosampler

February 18th, 2019, by

We are very excited to announce the launching of our new Spinsolve Autosampler.  It enables up 20 separate samples to be measured in any order and can be fitted to all Spinsolve models.  We have been developing this for some time, and already have quite a number of units with some of our reference customers who tell us they are delighted with its operation, functionality and high quality construction.

The Autosampler is particularly useful for customers who often have a series of samples to run on their benchtop NMR and want to save the hassle of having to keep coming back to exchange samples. Another benefit is the ability to increase utilization by setting up a queue of experiments to run on their Spinsolve overnight.

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DEA awards contract to Magritek Inc. to supply 80 MHz benchtop NMR spectrometers complete with autosamplers for forensic applications.

December 5th, 2018, by

Malvern, PA, USA, 4th December 2018: Magritek announces that it has been awarded a major contract by the US Drug Enforcement Administration (DEA) for two Spinsolve 80 Carbon benchtop NMR spectrometers. The purchase was made through a competitive award process and will allow DEA laboratories in Virginia and California to utilize the latest benchtop NMR technology to assist in forensic analysis applications.

Speaking about this prestigious award, Magritek Inc’s CEO, Dr Hector Robert, says

“We are very excited to be awarded this contract by the DEA. The selection of the 80 MHz Spinsolve instrument with 1H, 19F and 13C nuclei provides a versatile system suited to the analysis of many substances studied in forensic science. The systems are supplied with autosamplers which enable the measurement of multiple samples with an automated and efficient workflow.”

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Boron NMR Spectroscopy

November 29th, 2018, by

There are two naturally occurring NMR active nuclei of Boron, 11B (80.1%) and 10B (19.9%). Both nuclei are quadrupolar with spin of greater than ½. 11B has a spin of 3/2 and 10B is spin 3. In terms of sensitivity, 11B is the better nucleus to use as it has a higher natural abundance, a higher gyromagnetic ration, and a lower quadrupole moment. A Spinsolve benchtop NMR spectrometer with a proton frequency of 60 MHz can be configured to measure the 11B NMR signal which has a frequency of 19.2 MHz.

The 11B NMR spectrum of a 0.23 M solution Sodium tertraphenylborate in MeOH-d4 is shown below. The first spectrum shows the excellent sensitivity of Spinsolve using just 8 scans to acquire a spectrum in only 16 seconds.

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Live Benchtop NMR monitoring of Corning Flow Reactors at Achema

June 11th, 2018, by

At the Achema conference this week in Frankfurt we have a joint booth with Corning Advanced Flow Reactors.  We are running a live Spinsolve Benchtop NMR reaction monitoring setup in combination with a Corning Advanced Flow Reactor.  If you are Achema, please come and visit us at our joint booth with Corning AFR Hall 9.2 / Booth A32 and see the powerful combination of Corning Flow Reactors and Magritek Benchtop NMR.

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Characterizing Fatty Acids with advanced multinuclear NMR methods

April 6th, 2018, by

Download the full application note by clicking here (PDF)

Fatty acids consist of long carbon chains ending with a carboxylic acid on one side and a methyl group on the other. Most naturally occurring fatty acids have an even number of carbon atoms and can be either saturated or unsaturated. Unsaturated fatty acids have one or more double bonds between carbon atoms. Typical fatty acids found in vegetable oils are saturated palmitic acid (C16:0) and stearic acid (C18:0), as well as oleic acid (C18:1) with a single double bond starting at carbon nine (omega-9), linoleic acid (C18:2) with two double bonds starting at position 6 (omega-6), and alpha-linolenic acid with three double bonds starting at position 3 (omega-3).
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Thought Leader Interview: Prof Patrick Giraudeau

February 19th, 2018, by

A fascinating thought leader interview with Prof Patrick Giraudeau from the University of Nantes discusses how his group uses their Spinsolve benchtop NMR spectrometer for applications such as reaction monitoring, edible oil analysis and implementing ultrafast 2D NMR.

Benchtop NMR systems are better suited to reaction monitoring than high-field systems

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NMR spectroscopy outdoors at a natural gas plant

February 7th, 2018, by

Professor Mike Johns at the University of Western Australia shared this story about doing NMR outdoors with one of their Spinsolve spectrometers. The outdoor environment presents a number of challenges for any analytical instrument and not normally a place you would find NMR spectrometers. Great to hear the trial was successful. Details and pictures below.

In collaboration with Chevron and Woodside, the Fluid Science and Resources Research Group at the University of Western Australia (UWA) trialled a ppm oil-in water measurement protocol built around solid phase extraction and a Magritek 1H 43 MHz Spinsolve benchtop NMR spectrometer. This occurred in October 2017 on the Woodside Pluto LNG plant in North West Australia. Measurements were performed outside, adjacent to the waste water treatment plant, using the SPE-NMR apparatus shown below. The trial was successful with measurements being consistent with laboratory data over a two week period.

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13C NMR of Cholesterol on an 80 MHz magnet

June 14th, 2017, by

Cholesterol is an essential molecule found in all animals and is a structural component of animal cell membranes. It is the reason why animal cells are flexible and animals can move, unlike plant cells which have rigid cell walls. Cholesterol is a sterol and the cells in your body synthesize about 1 gram every day.

With recent advances in the performance of benchtop NMR, such as the 80 MHz Spinsolve 80, it is interesting to see the 13C NMR spectra from molecules such as Cholesterol.  With a molecular weight of 386 g/mol and 27 carbon atoms it is a larger molecule than is typical measured on a Carbon-13 capable benchtop NMR spectrometer. Because there are more peaks to resolve, both the sensitivity and resolution of the instrument are tested with this measurement.

The 1D proton-decoupled 13C NMR spectrum of a 400 mM sample of Cholesterol measured by a Spinsolve 80 is shown in the figure below. Because 13C has a lower gyromagnetic ratio than protons, the 13C Larmor frequency is 20 MHz. The region between 20 ppm and 45 ppm has been expanded to show how the carbon peaks are resolved.

Spinsolve 80: Quinine HSQC-ME example

May 30th, 2017, by

One of the advanced features of the Spinsolve 80 is the ability to run a Multiplicity Edited HSQC, also known as HSQC-ME.  This powerful 2D NMR sequence has proton in the horizontal (f2) axis and carbon in the vertical (f1) axis.  The peaks appear where a proton is connected to a carbon atom.  Additional information about “multiplicity” is given by the sign of the peak, just like in a DEPT experiment.  Positive peaks (red) are either CH or CH3, while negative peaks (blue) are from CH2. This additional information really helps with correct peak assignment.

The example below is from an HSQC-ME experiment run on a sample of Quinine and shows all the peaks uniquely resolved and assigned.

About andrew

Andrew is the CEO of Magritek and has led the company from its foundation as a University spin out company to its current position as a fast-growing, profitable exporter. He brings both commercial and technical experience to the company having worked in senior management roles for companies in Sydney and London. Andrew has a PhD in Physics from Massey University, is a 2011 Sir Peter Blake Emerging Leader and was a member of the team that won the 2010 Prime Minister’s Science Prize.