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MOF2018 6th International Conference, Auckland, 9-13 Dec 2018

November 12th, 2018, by

Magritek is excited to be supporting the MOF 2018 6th International Conference being held at The University of Auckland from 9-13 December.

The MOF 2018 6th International Conference is the sixth in the biennial series of international meetings that focus on MOF’s, COF’s and related open framework materials.   It will include a range of high-impact plenary representations, cutting edge talks, interactive poster presentations and convivial social events

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5th Winter Process Chemistry Conference in Manchester, UK 11 – 13 December, 2018

October 5th, 2018, by

Magritek is delighted to announce its participation in the 5th Winter Process Chemistry Conference in Manchester, UK from  11 – 13 December 2018. Please stop at our Booth and talk to our scientists about the capabilities and applications of the Spinsolve Benchtop NMR system. We are looking forward to seeing you at this event!

About 5th Winter Process Chemistry Conference & Exhibition

The 5th Winter Process Conference will showcase presentations from International Chemists covering all aspects of Process Development.

The speakers will discuss the latest issues in synthetic route design, development, and optimization, reactor design, work up and purification, crystallization, process engineering, hazard studies and quality and regulatory issues.

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1H and 13C Peak Assignments of Quinine Using 1D and 2D NMR Methods (Part 3)

July 15th, 2018, by

In my first two posts on using 1D and 2D NMR methods to assign the peaks of quinine (Figure 1), I looked at the 1H and 13C spectra.

 

Figure 1. Structure of quinine

 

In this post, I’m moving on to look at the 1H-13C HSQC spectrum. It’s worth spending a brief moment recapping what HSQC is all about and what info it gives you. In a nutshell, the HSQC experiment correlates proton and carbon chemical shifts over one chemical bond. Another way to put this is that a cross-peak in an HSQC spectrum says, “The proton with this chemical shift is directly attached to the carbon with that chemical shift”. By convention, HSQC spectra are presented with 1H shifts along the horizontal axis and 13C shifts along the vertical axis.

Some variants of HSQC also encode into the phases of the cross-peaks additional information about how many hydrogen atoms are attached to each carbon atom. This is sometimes referred to as multiplicity or DEPT editing. In the multiplicity-edited HSQC spectrum, it is conventional for the CH and CH3 groups to have positive phase, and the CH2 groups to have negative phase, just as in a DEPT-135 spectrum. Figure 2 shows the multiplicity-edited HSQC (“HSQC-ME”) spectrum of our 400 mM quinine sample. The CH2 signals are shown in blue and the CH and CH3 signals in red.

 

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Quantification of hydrocarbon content in water analysis at ppm level using benchtop NMR

June 20th, 2018, by

The permitted hydrocarbon content of discharged water from offshore oil and gas exploration is becoming increasingly limited by more stringent legislation. This creates the demand for measurement methods that are sensitive enough to detect contaminants at ppm level, but also compact and robust to field conditions. The group of Professor Mike Johns at the University of Western Australia in Perth has developed a benchtop NMR method to quantify the hydrocarbon content in water at the ppm level.


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1H and 13C Peak Assignments of Quinine Using 1D and 2D NMR Methods: Part 1

June 7th, 2018, by

Assigning peaks in the NMR spectrum is a fundamental part of structure verification. Depending on a variety of factors including the size and complexity of the molecule, and the field strength the NMR data are collected at, this can be a straightforward exercise or an extremely challenging one! For example, in the case of a fairly simple compound like lidocaine, it is relatively easy to assign all of the peaks directly in the 1H spectrum using a 43 MHz benchtop NMR spectrometer. However, as a compound’s molecular weight increases so the spectra tend to become more complex, with more resonances and, inevitably, more signal overlap. Assigning the peaks thus becomes significantly more challenging, which is where collecting 2D NMR spectra can help with completing the assignments.

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Wageningen University & Research uses the Spinsolve 60 MHz System as Part of Their Undergraduate Teaching Program

February 21st, 2018, by

Wageningen University & Research (WUR) is formed from the collaboration between Wageningen University and the Wageningen Research foundation. With the mission “to explore the potential of nature to improve the quality of life,” its staff and students work in the domain of healthy foods and living environments. Dr Teris van Beek is a Lecturer in the Department of Agrotechnology & Food Sciences. Among his responsibilities is the coordination of the undergraduate course in analytical chemistry where 220 molecular life sciences and biotechnology students are introduced to practical spectroscopy each year (UV, IR, MS, NMR, structure elucidation).


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AsCA CRYSTAL 32, Auckland, 2-5 Dec 2018

November 12th, 2018, by

Magritek  is delighted to be supporting the AsCA 2018 CRYSTAL 32 Conference being held at The University of Auckland from 2-5 December 2018.

The AsCA 2018 CRYSTAL 2018 conference will showcase outstanding science from Asia, Australia and New Zealand, and from around the world, and will be presented in three streams covering diverse topics in structural biology, chemical crystallography, crystal engineering, materials science, physics and fundamental science, and methods including instrumentation, techniques and computation.

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Harrisburg University Uses the Spinsolve 60 MHz System as Part of Their Undergraduate Teaching Program

June 27th, 2018, by

Dr Catherine Santai is an Associate Professor of Chemistry & Biochemistry and Program Lead of the Integrative Sciences program at Harrisburg University of Science & Technology. The program utilizes a number of analytical techniques teaching undergraduates about their use, giving them the experience ahead of entering research or industrial roles in later life. So far, the Magritek 60 MHz Spinsolve Benchtop NMR Spectrometer has been used in the Organic Chemistry and Biochemistry laboratory sessions. These provide invaluable hands-on lessons about NMR techniques and analysis of a variety of compounds. NMR is used alongside FTIR (Fourier transfer infrared), AAS (atomic absorption), UV-VIS (ultraviolet – visible) and fluorescence spectroscopies.

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Live Benchtop NMR monitoring of Corning Flow Reactors at Achema

June 11th, 2018, by

At the Achema conference this week in Frankfurt we have a joint booth with Corning Advanced Flow Reactors.  We are running a live Spinsolve Benchtop NMR reaction monitoring setup in combination with a Corning Advanced Flow Reactor.  If you are Achema, please come and visit us at our joint booth with Corning AFR Hall 9.2 / Booth A32 and see the powerful combination of Corning Flow Reactors and Magritek Benchtop NMR.

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Measurement of oil adulteration

May 7th, 2018, by

Due to their high retail value, some edible oils are often blended wilfully with other more inexpensive vegetable oils. Two recent publications by Kim et al. and Krause et al. in international journals were able to demonstrate that Spinsolve 1H benchtop NMR spectroscopy is a possible cost-effective method for discriminating the authenticity of some vegetable oils.

Patchouli oils

Overlaid 60 MHz 1H‑NMR spectra of genuine patchouli oils spiked with 9 different adulterants at 20%.

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Organic18 – 24th RACI Organic Division National Conference – Perth, Australia, 2-6 December 2018

November 12th, 2018, by

Magritek is delighted to be participating at the 24th RACI Organic Division National Conference Organic18 which is being held at The University of Western Australia from 2-6 December 2018.

You can find us at Booth 7 where we will be happy to answer any questions you may have about the capabilities and applications of the high performance Spinsolve Benchtop NMR Spectrometers.   We look forward to seeing you there.

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Robot Chemist publication in Nature includes a Spinsolve benchtop NMR spectrometer

July 24th, 2018, by

The group of Professor Lee Cronin at the University of Glasgow has combined machine learning with a chemical reaction system to speed up the discovery of new chemical reactions, which is an inherently unpredictable and time consuming process. This new approach of an Organic Synthesis Robot uses a Spinsolve Benchtop NMR spectrometer as an integral component. Their work has just been published in the prestigious journal Nature: J. M. Granda, L. Donina, V. Dragone, D.-L. Long and L. Cronin, Nature 559, 377–381 (2018), DOI: 10.1038/s41586-018-0307-8

Photograph of the chemical robot

The photo shows the impressive setup of the chemical robot with 27 pumps, valves and six reactors, as well as NMR, IR and MS spectrometers for real-time analytics.

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The APT Experiment

June 7th, 2018, by

The Attached Proton Test (APT) is a very useful experiment that, like DEPT, provides information about how many hydrogens or protons are attached to a particular carbon atom. Both DEPT and APT do this by “editing” the spectrum so that the carbon signals point either up or down depending on the number of attached hydrogens. APT differs from DEPT in several significant ways, though. The first is that quaternary carbons (i.e. carbons that bear no hydrogens) are retained in the APT spectrum, whereas they are absent in DEPT (though there are variants of the traditional DEPT experiment that do retain the quaternary signals). In APT, quaternary and methylene carbons point down by convention, while methyl and methine carbons point up. Figure 1 shows a comparison of a conventional carbon, APT and DEPT-135 spectra of a sample of propyl benzoate.

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Characterizing Fatty Acids with advanced multinuclear NMR methods

April 6th, 2018, by

Download the full application note by clicking here (PDF)

Fatty acids consist of long carbon chains ending with a carboxylic acid on one side and a methyl group on the other. Most naturally occurring fatty acids have an even number of carbon atoms and can be either saturated or unsaturated. Unsaturated fatty acids have one or more double bonds between carbon atoms. Typical fatty acids found in vegetable oils are saturated palmitic acid (C16:0) and stearic acid (C18:0), as well as oleic acid (C18:1) with a single double bond starting at carbon nine (omega-9), linoleic acid (C18:2) with two double bonds starting at position 6 (omega-6), and alpha-linolenic acid with three double bonds starting at position 3 (omega-3).
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