A recently published article in Biotechnology and Bioengineering, co-authored Prof. Dr. Bernhard Blümich, one of the founders of Magritek, shows that using the Spinsolve to non-invasively monitor fermentation is a chemically specific and robust way of monitoring changes in complex, opaque media.
Blümich et. al. followed the changes in chemical composition in the fermentation broth of two microbes, identifying the nutrients consumed and the formation of products. The results obtained from online monitoring using the Spinsolve were validated by analysing off-line samples using established methods: HPLC and high-field NMR spectroscopy. Despite reduced spectral resolution compared to high-field, both applications showed that the Spinsolve in a reaction-monitoring set-up shows great promise for monitoring complex biotechnological processes at research and practical industrial scales at a fraction of the cost of existing systems.
Reference: D. Kreyenschulte, E. Paciok, L. Regestein, B. Blümich and
J. Büchs, ‘Online Monitoring of Fermentation Processes Via
Non-Invasive Low-Field NMR‘, Biotechnol. Bioeng., 2015. DOI: 10.1002/bit.25599